脾切除后脾移植血小板变化的实验观察  

THE EXPERIMENTAL OBSERVATION ON THE PLATELETS CHANGES AFTER SPLEEN TRANSPLANTATION AND SPLENECTOMY

作　　者：周军[1] 郭利光[1] 孙晓光[1] 欧阳军[1] 

机构地区：[1]新疆石河子大学医学院第一附属医院急诊外科,石河子832008

出　　处：《现代预防医学》2011年第4期716-717,共2页Modern Preventive Medicine

摘　　要：[目的]通过建立脾细胞移植和脾片移植动物模型观察两种移植途径后血小板恢复状况。[方法]Wistar大鼠36只,随机分为3组,其中A组为对照组,行脾切除术,B组为脾片移植组,C组为脾细胞移植组,在建立模型前、及模型成功后1周、4周、8周抽血,检测血小板水平并进行比较。[结果]A组脾切除后B组移植后8周血小板接近正常(P﹥0.05);C组移植后血小板逐渐升高(P﹤0.05);A、B、C组的血小板相比差异无统计学意义(P﹥0.05),而在术后8周B组和A和C组的血小板差异有统计学意义(P﹤0.05),而A和C组的血小板相比差异无统计学意义(P﹥0.05)。[结论]脾切除后在移植8周后血小板可恢复至正常,而脾细胞移植后则对血小板无明显影响。[Objective] To investigate the recovery of platelets in spleen transplantation and spleen cell transplantation animal models.[Methods] 36 wistar rats were randomly divided into 3 groups.Group A was control group and was undergone splenectomy.Group B was underwent spleen transplantation and Group C was underwent spleen cell transplantation.The platelets counts were measured in 1 week,4 week and 8 week after establishing model.[Results] Platelets counts were close to normal level in group A and in group B after splenectomy for 8 weeks（P﹥0.05）.Platelets counts in group C were increased gradually after transplantation（P﹤0.05）;There was no significantly difference in Platelets counts in the 3 groups and there was no significantly difference after splenectomy for 8 weeks among the 3 groups（P﹤0.05）.The A and C groups showed no significant difference in platelet（P﹥0.05）.[Conclusion] After splenectomy for 8 weeks after transplantation,platelet recovered to normal,and spleen cell transplantation did not show significant effect on platelets.

关 键 词：脾切除 自体脾组织移植 血小板 

分 类 号：R322.2[医药卫生—人体解剖和组织胚胎学]