转化生长因子β受体的研究进展  

Study of Tranforming Growth Factor β Receptor.

作　　者：唐桂林[1] 苏先狮[1] 

机构地区：[1]湖南医科大学附属第二医院,长沙410011

出　　处：《生物化学与生物物理进展》1999年第5期443-445,共3页Progress In Biochemistry and Biophysics

摘　　要：转化生长因子β受体为胞膜蛋白， 存在５ 种形态， Ⅲ型受体主要是调节受体与配体之间的亲和力及Ⅱ型受体的膜上表达． 功能性受体则主要为Ⅰ、Ⅱ型． Ⅰ、Ⅱ型受体在介导信号传递时相互配合， 又存在分工不同：Ⅰ型受体为介导转化生长因子β促细胞外基质合成的信号通道． 而Ⅱ型受体则与细胞的增殖。Tranforming growth factor β receptor, divided into five types, are membrane protein. The functin of type Ⅲ receptor is regulating the affinity between receptor and ligand as well as the expression of type Ⅱ receptor. Type Ⅰ and type Ⅱ receptor are functional receptors. They cooperate closely while the signal transduction, and on the other hand. They function differently: type Ⅰ receptor acts as the signal pathway by which transforming growth factor β stimulate the increasing synthesis of extracellular matrix ; type Ⅱ receptor has closely relationship to the proliferate and differentiate cells.

关 键 词：转化生长因子Β 受体 信号传递 生物作用 

分 类 号：Q516[生物学—生物化学]