氧化乐果中毒大鼠膈肌的病理及血肌酸激酶变化  

Change of Creatine Kinase and Pathology of Diaphragm in Rats With Omethoate Poisoning

作　　者：刘兆润[1] 董均树[2] 夏红[2] 吕萍[2] 

机构地区：[1]鞍山钢铁集团公司总医院,鞍山114002 [2]吉林大学第一医院

出　　处：《内科急危重症杂志》2010年第6期328-329,332,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:探讨氧化乐果中毒大鼠膈肌损伤致呼吸肌麻痹(RMP)的机制。方法:60只Wistar大鼠随机分为3组:盐水对照组、中毒组、阿托品治疗组,测定各组中毒后24h血液胆碱酯酶(ChE)和肌酸激酶(CK)水平,观察中毒后不同时间膈肌组织病理及超微结构的改变。结果:中毒组和阿托品治疗组血CK明显升高,部分大鼠膈肌发生坏死。结论:氧化乐果中毒大鼠膈肌损伤严重,膈肌纤维坏死是急性有机磷农药中毒(AOPP)致RMP的可能原因之一。Objective：To explore the mechanism of respiratory muscle paralysis （RMP） induced by diaphragm injuries in rats with omethoate poisoning. Methods：Sixty wistar rats were randomly divided into 3 groups：control group,poisoning group and atropine treatment group. Levels of blood cholinesterase （ChE） and creatinekinase （CK） were measured after poisoning. The pathological changes of diaphragm at different times were observed. Results：Blood CK increased obviously in poisoning group and atropine treatment group,and necrosis of diaphragm developed in some of the rats. Conclusions：Diaphragm was severely injured in rats with omethoate poisoning,and fibrotic necrosis of the diaphragm might be one of the reasons that causing RMP induced by acute organophosphate pesticide poisoning.

关 键 词：呼吸肌麻痹 膈肌损伤 氧化乐果 大鼠 

分 类 号：R595.4[医药卫生—内科学]