核转录因子-κB在急性肾损伤细胞凋亡中的作用  

Role of NF -κB in apoptosis induced by acute kidney injury

作　　者：俞隼[1] 顾勤[1] 刘宁[1] 

机构地区：[1]南京医科大学鼓楼临床医学院ICU,江苏210008

出　　处：《中国急救医学》2010年第12期1137-1139,共3页Chinese Journal of Critical Care Medicine

摘　　要：急性肾损伤是临床常见的危重症,病死率高,缺乏有效的防治措施.研究发现,细胞凋亡在急性肾损伤的发生机制中起着重要作用.核转录因子-κB （NF-κB）是具有多向转录调节作用的核蛋白因子,与细胞凋亡关系密切,参与多种凋亡相关基因的转录调控,具有抑制和促进细胞凋亡的双向作用.本文就NF-κB信号传导在急性肾损伤细胞凋亡中的作用作一综述.Acute kidney injury（AKI） is common in critically ill patients and is associated with significant mortality, but the options outside of renal replacement therapy are nonexistent at present. Several studies showed that tubular cell apoptosis is linked to the development of AKI. The NF -κB transcription factor plays a key role in the regulation of apoptosis by modulating expression of a wide range of cell death control molecules. In this article, we elucidate role of NF -κB in apoptosis induced by AKI.

关 键 词：核转录因子-ΚB 细胞凋亡 急性肾损伤 

分 类 号：R692[医药卫生—泌尿科学]