鸡骨香化学成分研究  

Study on Chemical Constituents from Croton crassifolius Geisel

作　　者：陈书红[1] 任风芝[1] 李丽红[1] 高月麒 王宁[1] 

机构地区：[1]华北制药集团新药研究开发有限责任公司天然药物室,石家庄050015

出　　处：《中国药学杂志》2010年第24期1907-1909,共3页Chinese Pharmaceutical Journal

摘　　要：目的研究鸡骨香的化学成分。方法通过硅胶柱色谱及高效液相色谱等方法对鸡骨香进行分离,根据理化性质和光谱数据鉴定化学结构。应用白细胞弹性蛋白酶抑制剂高通量的筛选模型评价化合物的抗炎活性。结果从鸡骨香中分离得到7个萜类化合物,分别鉴定为cyperenoic acid(1);石岩枫二萜内酯B(mallotucin B,2);chettaphan inⅡ(3);chettaphaninⅠ(4);山藿香定(teucvidin,5);6-[2-(furan-3-yl)-2-oxoethyl]-1,5,6-trimethyl-10-oxatricyclo[7.2.1.02,7]dodec-2(7)-en-11-one(6);pendu liflaworosin(7);其中有2个化合物对人白细胞弹性蛋白酶有较强的抑制活性;结论化合物3,5,6,7为首次从鸡骨香中分离得到,化合物3,7显示有抗炎活性。OBJECTIVE To study the chemical constituents of Croton crassifolius Geisel. METHODS The compounds were i- solated by chromatography on silica gel and HPLC. Their structures were identified by their physical, chemical and spectral analysis. A high through-put screening method was used to explore the HLE inhibitor. RESULTS Seven compounds were isolated and identified as cyperenoic acid （ 1 ）, mallotucin B （ 2 ）, chettaphanin 1] （ 3 ）, chettaphanin I （4）, teucvidin （ 5 ）, 6- [ 2- （furan-3-yl） -2-oxoethyl ] - 1,5,6-trimethyl-10 -oxatricyclo [ 7.2. 1.0^2.7 ] dodec-2 （ 7 ） -en-11 -one （ 6 ） and penduliflaworosin （ 7 ）. Among them, there are two compounds showed strong inhibitor activity against human leukocyte elastase. CONCLUSION Compound 3, 5, 6 and 7 were isolated from this plant for the first time. And compound 3 and 7 had significant anti-inflammation activity.

关 键 词：鸡骨香 chettaphanin penduliflaworosin 二萜 抗炎活性 

分 类 号：R284[医药卫生—中药学]