抗抑郁干预对围放疗期癌症患者情绪状况的影响  

Effect of antidepressant intervention on mood state of at or around the time of radiation therapy

作　　者：陈建华[1] 李桂兰[2] 汪达山[1] 董江宁[1] 潘明[1] 刘新民[2] 

机构地区：[1]皖南医学院附属池州市人民医院,池州247000 [2]皖南医学院附属池州市人民医院心理学教研室,池州247000

出　　处：《中华行为医学与脑科学杂志》2010年第12期1074-1075,共2页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项目：池州市人民医院科研基金资助项目（200906）

摘　　要：目的探讨抗抑郁干预对围放疗期癌症患者情绪状况的影响。方法对62名放疗患者按接受放疗的时间顺序分为药物干预组（接受抗抑郁药物治疗6周）和对照组，采用汉密顿焦虑量表（HAMA）、汉密顿抑郁量表（HAMD）测查。结果HAMA、HAMD测查结果显示，抗抑郁药物干预组与对照组比较，放疗前焦虑、抑郁差异无显著性；放疗期间的焦虑[干预组（6．41±2．30）分，对照组（9．29±5．62）分]、抑郁[干预组（8．80±3．05）分，对照组（12．22±8．32）分]差异有显著性（P〈0．05）；放疗结束后2周的焦虑[干预组（4．90±1．71）分，对照组（12．32±7．24）分]、抑郁[干预组（6．83±2．47）分，对照组（16．09±8．61）分]差异有显著性（P〈0．01）。结论应重视癌症放疗患者不同时期的心理状况，并应用抗抑郁药物，缓解其焦虑、抑郁情绪。Objective To explore the effect of antidepressant intervention on mood state of at or around the time of radiation therapy. Methods 62 hospitalized patients with cancer receiving radiotherapy were divided into two groups by the order of the time when they accept the radiotherapy which called intervention group （ antidepressant fluoxetine group） and control group. And the two groups patients filled out Hamihou Anxiety Scale（ HAMA） and Hamilton Depression Scale （HAMD） at or around the time of radiation therapy to investigate the effects of fluoxetine on anxiety and depression. Results The scores of HAMA and HAMD showed that there was no differences between the intervention group and the control group before the radiotherapy. There was significant difference during the radiotherapy （ 6.41 ±2.30 ） vs （ 9.29± 5.62 ） ; （ 8.80 ±3. 048 ） vs （ 12.22 ± 8.32 ） and two weeks after the end of the radiotherapy （4.90 ± 1.71 ） vs （ 12.32 ± 7.24） ; （6.83 ±2.47） vs （ 16.09 ± 8.61 ） between antidepressant fluoxetine group and control group（P 〈 0.05 ）. Conclusion More attention should be paid to mental health and antidepressant can alleviate anxiety and depression of the cancer patients＇at or around the time of radiotherapy.

关 键 词：癌症 放射治疗 心理状况 抗抑郁药物 

分 类 号：R473.73[医药卫生—护理学]