中国南海短指软珊瑚Sinularia sp.的化学成分研究(英文)  

Chemical constituents of Sinularia sp.from the South China Sea

作　　者：贾睿[1] 严小红[2] 何培民[1] 郭跃伟[3] 

机构地区：[1]上海海洋大学水产与生命学院,上海201306 [2]广州市药品检验所,广东广州510160 [3]中国科学院上海药物研究所,上海201203

出　　处：《中国海洋药物》2010年第6期7-11,共5页Chinese Journal of Marine Drugs

基　　金：supported by National Science & Technology Major Project(2009ZX09301-001);Natural Science Foundation of China(Nos.21072204,30730108,and 20721003);STCSM International Cooperation Project between SIMM/China and ICB/Italy(No.10540702900);Science Foundation for the Excellent Youth Scholars of Shanghai(ssc09001);Scientific Research Foundation for PhD of Shanghai Ocean University;partly founded by the NSFC-TRF International Cooperation Project(No.20911140471)

摘　　要：目的研究南海短指软珊瑚的化学成分。方法综合利用各种层析方法分离和纯化化合物,并利用光谱学和理化性质来鉴定化合物结构。结果从中分离得到8个甾体化合物,分别鉴定为24-methylcholesta-5,24(28)-diene-3β,7β3,19-triol(1)、24-methylcholesta-5,24(28)-diene-3β,7β,19-triol-7β-monoacetate(2)、litosterol(3)、24-methylcholesta-5,24(28)-diene-3β,7β,19-triol-3β,7β,19-triacetate(4)、24-methylcholesta-24(28)-ene-3β,5α,6β,19-tetrol(5)、hyrtiosterol(4α-methyl-2β,3β,8β,11β-tetrol-5α-ergost-22(23),24(28)-diene)(6)、5,6-epoxylitosterol(7)、armatinol A(8)。结论化合物1～8都是首次从该属软珊瑚中分离得到。Objective To investigate chemical components of Sinularia sp..Methods The chemical constituents were isolated and purified by various chromatographic techniques.Their structures were determined on the basis of physical properties and spectroscopic data.Results Eight compounds were isolated and elucidated as 24-methylcholesta-5,24（28）-diene-3β,7β,19-triol（1）,24-methylcholesta-5,24 （28）-diene-3β,7β,19-triol-7β-monoacetate（2）,litosterol（3）,24-methylcholesta-5,24（28）-diene-3β, 7β,19-triol-3β,7β,19-triacetate（4）,24-methylcholesta-24（28）-ene-3β3,5α,6β,19-tetrol（5）,hyrtios-terol （4α-methyl-2β,3β,8β,11β-tetrol-5α-rergost-22（23）,24（28）-diene）（6）,5,6-epoxylitosterol（7）, armatinol A（8） respectively.Conclusion Compounds 1～8 were isolated from this genus for the first time.

关 键 词：短指软珊瑚 化学成分 甾体 

分 类 号：R959.133[医药卫生—药学] R917