欣普贝生用于未足月胎膜早破引产临床观察  

作　　者：汤则男[1] 张欢[1] 孙国强[1] 

机构地区：[1]湖北省妇幼保健院产科,湖北武汉430070

出　　处：《医学信息（中旬刊）》2011年第2期659-660,共2页Medical Information Operations Sciences Fascicule

摘　　要：目的:探讨欣普贝生用于未足月胎膜早破促宫颈成熟引产的临床效果及安全性。方法:选择200例孕35～36+6周单胎、头位、无宫缩的初产妇为实验组,使用欣普贝生一枚,横置于阴道后穹窿内;同期使用催产素静滴组作为对照组,对照组予5%葡萄糖500ml+缩宫素2.5单位静滴。观察宫颈成熟度,分娩方式、产后出血量以及新生儿情况。结果:用药后实验组宫颈成熟度明显增高,24h阴道分娩率明显增加,剖宫产率明显下降,差异有统计学意义(P<0.05);而产后出血量及新生儿窒息情况,两组比较差异无统计学意义(P>0.05)。结论:欣普贝生用于未足月胎膜早破引产疗效可靠,但在引产过程中需严密观察宫缩及胎心,减少不良反应的发生。Objective：To exlore the clinical effects and safety of dinopmstone for cervical ripening and artificial labor in preterm prematurerup rupture of membranes. Methods ：200 primipara at 35 to 36 ＋ 6 weeks of gestation single birth, head presentation without uterine contraction were randomly divided into observation group and control group, 100 cases in each group. One piece of dJnoprostone was put into the vag4nal posteri or fornix of gravida in observe group, and Oxytocin 2.5 U added in 50 g·L^-1 glucose of 500 mL was used intravascularly in control group. The maternal cervical Bishop score, vaginal delivery rate, cesarean section rate postpartum hemorrhage, and neonatal asphyxia rate were compared between two groups. Results：The maternal cervical Bishop score of observe group were higher than those of control group （ P 〈 0.05 ） ,The vaginal delivery rate in 24 hours of observe group were higher than those of control group （ P 〈 0.05 ） ;The cesarean section rate of observe group was lower than that of control group （ P 〈 0.05 ）. There were no significant difference in post partumhemorrhage and neonatal as phyxia rate between two groups （ P 〉 0. 05 ）. Conclusion：Dinoprostone was effective and safe for cervical ripening and artificial labor in preterm prematurernp rupture of membranes, but we should observate fetal heart and uterine contraction carefully, in order to decrease the adverse reaction.

关 键 词：欣普贝生 未足月胎膜早破 引产 

分 类 号：R714.433[医药卫生—妇产科学]