氨溴索对单肺通气患者围术期炎性反应的抑制作用  

Inhibitory effect of ambroxol on perioperative inflammatory responses in patients undergoing one lung ventilation

作　　者：钟日胜[1] 黄燕娟[1] 曾建业[1] 黄冰[2] 何二宁[1] 冉雪莲[1] 

机构地区：[1]广西医科大学第三附属医院麻醉科,南宁市530031 [2]广西壮族自治区肿瘤防治研究所麻醉科

出　　处：《临床麻醉学杂志》2010年第11期944-946,共3页Journal of Clinical Anesthesiology

基　　金：广西自然科学基金资助项目(0640197)

摘　　要：目的评价小剂量氨溴索对单肺通气(OLV)患者炎性反应的影响。方法剖胸手术OLV患者30例,随机均分为两组:A组于OLV前25min静脉输注氨溴索1mg/kg(生理盐水稀释至100ml,5ml/min),B组静脉输注等容量生理盐水作为对照。于麻醉诱导前(T0)、OLV前即刻(T1)、OLV30min(T2)、1h(T3)、2h(T4)、恢复双肺通气(TLV)1h(T5)、2h(T6)和术后24h(T7)采集桡动脉血样,测定血清肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-6、IL-8的浓度,并行WBC和中性粒细胞(PMN)计数。结果与B组比较,A组的IL-6在T5～T7时、IL-8在T3～T7时、TNF-α在T4～T7时、WBC计数在T4～T7时、PMN计数在T5～T7时均降低(P<0.05或P<0.01)。结论氨溴索1mg/kg可减轻OLV患者炎性反应。Objective To study the inhibitory effect of ambroxol on perioperative inflammatory responses in patients undergoing one-lung ventilation（OLV）.Methods Thirty patients undergoing thoracic surgery and OLV were randomly divided into two groups with 15 cases each. The patients were given OLV during intrathoracic procedure,in group A ambroxol 1 mg/kg in 100 ml of saline was injected in 20 min at 25 min before OLV,while in group B equal volume of injection normal saline was infused as the controls. Blood samples were taken before anesthesia（T0）,before OLV（T1）,at 30 min（T2）,1 h（T3）,2 h（T4） during OLV 1 h（T5）,2 h（T6）after OLV,and 24 h（T7） after operation for detecting the serum levels of tumor necrosis factor α（TNF-α）,interleukin（IL）-6 and IL-8,and accounting WBC and PMN. Results Serum levels of TNF-α at T4-T7,IL-6 at T5-T7,and IL-8 at T3-T7 were significantly lower in group A than those in group B（P0.05 or P0.01）. So did the counts of WBC at T4-T7 and PMN at T5-T7（P0.05 or P0.01）.Conclusion Ambroxol 1 mg/kg injected before OLV may attenuate perioperative inflammatory responses in patients undergoing thoracic surgery.

关 键 词：氨溴索 单肺通气 炎性反应 

分 类 号：R614[医药卫生—麻醉学]