药动学-药效学结合模型的研究进展及应用  

Recent Advances and Application of Pharmacokinetic-pharmacodynamic(PK-PD) Modeling

作　　者：孙敏捷[1] 许颖[1] 

机构地区：[1]中国药科大学药学院,南京210009

出　　处：《中国现代应用药学》2010年第12期1084-1089,共6页Chinese Journal of Modern Applied Pharmacy

基　　金：国家重大新药创制科技重大专项(2009ZX09310-004)

摘　　要：目的综述药动学-药效学(PK-PD)结合模型的研究进展。方法对近十年来国内外发表的具有代表性的相关文章进行分析、整理和归纳,总结PK-PD结合模型的类型、程序及应用。结果 PK-PD结合模型有4种类型,其在新药研发,个体化给药和临床检测等方面都有广泛的应用,为临床用药提供了有力的指导。结论 PK-PD模型随着研究的深入不断完善,在药物开发和研究中发挥了重要的作用。OBJECTIVE To review the advances on pharmacokinetic-pharmacodynamic（PK-PD） modeling.METHODS On the basis of analysing and concluding the relevant articles for the last ten years,the types,programs and application of PK-PD modeling were summarized.RESULTS There are four kinds of pharmacokinetic-pharmacodynamic（PK-PD） modeling,which were widely applied on drug development,individual administration and clinical detection,providing useful information to guide clinical medication.CONCLUSION PK-PD modeling has been improved and plays important role in drug development with its deep study.

关 键 词：药动学 药效学 药动学-药效学结合模型 常用程序 研究进展 

分 类 号：R965[医药卫生—药理学]