CREM基因单链构象多态性与特发性生精功能障碍相关性初探  

Study on the relationship between CREM gene polymorphism and idiopathic spermatogenesis dysfunction

作　　者：王炯[1] 贾书花[2] 陈云霞[3] 武延隽[3] 苗聪秀[4] 王改琴[2] 

机构地区：[1]长治医学院附属和济医院妇产科,长治046011 [2]长治医学院组织胚胎学教研室 [3]长治医学院免疫教研室 [4]长治医学院附属和平医院生殖遗传中心

出　　处：《中国男科学杂志》2010年第12期14-17,共4页Chinese Journal of Andrology

基　　金：山西省高校科技研究开发项目(项目编号:20051251)

摘　　要：目的探讨cAMP反应元件调节物(cyclic AMP-responsive element modulator,CREM)与男性不育症中特发性生精障碍的关系。方法收集特发性无精子症患者外周血53例和特发性严重少精子症患者外周血45例,另以具有正常生育能力志愿者外周血30例作为对照,通过提取外周血DNA、PCR扩增、单链构象多态性(SSCP)对外周血中CREM基因进行检测。结果在26.4%的特发性无精子症和25%特发性严重少精子症患者中出现CREM基因的变异。结论在人类,CREM基因与精子的发生发育之间具有相关性,CREM基因参与人类精子的发生。Objective To analyze the relationship between the CREM gene polymorphism and idiopathic spermatogenesis dysfunction of male infertility. Methods The peripheral blood samples of 52 patients with azoospermia and 45 patients with serious oligospermia were collected respectively, and the peripheral blood samples of 30 volunteers with normal fertility were taken as controls. The CREM gene in patients with idiopathic spermatogenesis dysfunction were detected by PCR amplification and single-strand conformation polymorphism. Results CREM gene mutation was found in 26.4% of the patients with azoospermia and 25% of the patients with serious oligospermia. Conclusion CREM gene might be associated with or be involved in the process of spermatogenesis

关 键 词：CREM基因 不育 男性 

分 类 号：R698.2[医药卫生—泌尿科学]