复方中药祛肝脂合剂对脂肪肝大鼠抗氧化能力的影响  

Effect of Chinese Traditional Herbal Formulas Qu-Gan-Zhi Decoction on Antioxidative Effection of Non-alcoholic Steatohepatitis Rat

作　　者：陈枫[1] 袁婉丽[1] 唐坤华[1] 唐小平[1] 李世宁[2] 

机构地区：[1]泸州医学院附属医院,四川泸州646000 [2]泸州医学院病理教研室,四川泸州646000

出　　处：《成都中医药大学学报》2010年第4期59-61,共3页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：泸州医学院科研基金课题

摘　　要：目的:观察祛肝脂合剂的抗氧化能力。方法高脂饮食造脂肪肝模型;选用雄性SD大鼠随机分为空白对照组、模型组、祛肝脂合剂高、低剂量组,于造模第9周给药,4周后处死动物,心脏取血检查转氨酶、血脂、丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px),并取肝组织做病理检查。结果:祛肝脂合剂能降低转氨酶、血脂、MDA;升高SOD、GSH-PX,与模型组比较有显著性差异(P<0.05)。结论:祛肝脂合剂能减少氧自由基的产生从而减轻肝脏损害,有抗脂肪肝作用。Objective：To investigate the antioxidative effection of Qu-gan-zhi decoction.Methods：The rats were randomly divided into 4 groups： blank control group,fatty liver model group,experiment group of low dosage,and experiment group of high dosage.The non-alcoholic steatohepatitis model of male Sprague-Dawley rats was induced by the high-fat diet.9 weeks after the model is reproduced,Qu-gan-zhi decoction was administrated to animals of experiment groups by gavage.And 4 weeks after administration of medicine,the animals were killed and the bloods were obtained from heart of animals.The liver function,blood lipids,malondia-ldehyde（MDA）,superoxide dismutase（SOD） and glutathione（GSH-Px） were checked.And the histological analysis of liver was checked.Results：Qu-gan-zhi decoction can reduce aminotransferase,lipid levels of blood and MDA,at the some time increase activities of SOD and GSH-PX,It is significant difference from the fatty liver model group（P0.05）.Conclusion： Qu-gan-zhi decoction can reduce the production of oxygen free radicals,thus It can reduce the liver damage and have the function of Anti-fatty liver.

关 键 词：大鼠 脂肪性肝炎 祛肝脂合剂 

分 类 号：R285.5[医药卫生—中药学] R575.5[医药卫生—中医学]