大黄酸及其衍生物药理作用研究新进展  

Development of pharmacological effects of rhein and its derivatives

作　　者：李晓红[1] 李蒙[1] 陶艳蓉[2] 

机构地区：[1]中国医学科学院药用植物研究所,北京100193 [2]北京中医药大学东直门医院,北京100700

出　　处：《现代药物与临床》2010年第6期417-421,452,共6页Drugs & Clinic

基　　金：国家科技专项重大新药创制"与药效相关的中药质量评价关键技术研究"(200909502-021)

摘　　要：大黄酸是中药芦荟、大黄的主要成分之一,临床上用于治疗骨关节炎、糖尿病肾病等多种疾病,且具有协同抗肿瘤的作用。鉴于其较广泛的药理作用及低毒性、低成本等特点,大黄酸有望得到进一步开发与应用。综述近几年来对大黄酸及其衍生物在抗肿瘤、抗氧化、抗炎和对消化系统、肾脏、心血管系统、骨以及调脂等方面的药理作用研究进展。Rhein,a main constituent of Rhubarb,is a well-characterized anti-inflammatory agent which has been used for treatment of inflammatory diseases such as ostarthritis,diabetic nephropathy etc.It also has certain synergic antitumor effect.This paper reviews the recent studies on pharmacological actions,including anti-inflammation,anti-tumor,anti-oxidation,weight loss and lipid lowering of rhein and its derivatives.The effects of rhein and its derivatives on digestive system,kidney,heart,blood vessels and bone are also reviewed.

关 键 词：大黄酸 抗肿瘤 抗氧化 抗炎 

分 类 号：R282.710.5[医药卫生—中药学]