不同疗程聚乙二醇干扰素治疗对慢性乙型肝炎疗效的影响  

Effect of Different Courses of Pegylated interferon in Patients with Chronic Hepatitis B

作　　者：俞萍[1] 周红燕[1] 吴杭源[1] 

机构地区：[1]无锡市传染病医院,无锡214000

出　　处：《中国医药导刊》2010年第11期1914-1915,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:了解不同疗程聚乙二醇干扰素对慢性乙型肝炎疗效的影响。方法:所有59例慢性乙型肝炎病患均皮下注射聚乙二醇干扰素α-2a,180 g,每周一次。A组30例疗程24周,B组29例疗程48周。治疗结束后,随访24周。结果:在治疗结束时及结束后24周时,B组抗病毒效果以及改善肝纤维化的程度均优于A组。结论:延长聚乙二醇干扰素治疗时间,能明显提高抗病毒能力及抗纤维化能力。Objective：To investigate the effect of different courses of pegylated interferon in patients with chronic hepatitis B. Methods： All the 59 patients with chronic hepatitis B were treated with pegylated interferon α-2a 180μg subcutaneously, one time per week. The A group of 30 patients were administered for 24 weeks The B group of 29 patients were administered for 48 weeks. After the discontinuation of the medication, all the patients were followed up for 24 weeks. Results：At the end of the treatment and the end of 24-week of follow-up period, the effect of antiviral and improvement of liver fibrosis indexes on patients of B group is better than those in group of A. Conclusions： Extending the time of pegylated interferon treatment could significantly improve the ability of anti-virus and anti-fibrosis.

关 键 词：慢性乙型肝炎 聚乙二醇干扰索 抗病毒 抗纤维化 

分 类 号：R512.62[医药卫生—内科学]