榼藤子及其炮制品的急性毒性及对胃肠运动的影响  

Study on Acute Toxicity and Animal Gastrointestinal Activity of Crude and Processed Products of Entada phaseoloides

作　　者：肖二[1] 熊慧[1] 赵应红[2] 邓旭坤[1] 梅之南[1] 

机构地区：[1]中南民族大学药学院,湖北武汉430074 [2]云南西双版纳傣族自治州民族医药研究所,云南景洪666100

出　　处：《中药材》2010年第11期1704-1707,共4页Journal of Chinese Medicinal Materials

基　　金：国家科技支撑计划项目(2007BAI48B08)

摘　　要：目的:考察榼藤子炮制前后的急性毒性作用及对小鼠胃肠运动功能的影响。方法:采用灌胃给药的方式,观察榼藤子生品及不同炮制品对小鼠的急性毒性反应,并测定其LD50。采用小肠炭末推进法及甲基橙比色法,来考察榼藤子生品及炮制品对小鼠胃肠运动的影响。结果:榼藤子生品及炮制品1号、2号对小鼠的LD50分别为27.17、35.13、42.18 g/kg;榼藤子生品及炮制品能明显促进正常小鼠的肠蠕动,对阿托品所致小肠运动的抑制有明显的拮抗作用,但对新斯的明所致小肠运动的亢进无明显作用;榼藤子炮制前后高、中、低剂量组对正常小鼠胃排空均有明显抑制作用。结论:榼藤子经炮制后对正常和抑制状态的小鼠小肠运动有促进作用,对正常小鼠的胃排空有抑制作用,但安全性相对生品高。Objective：To study the acute toxicity of the crude and processed products of Entada phaseoloides and their effects on gastrointestinal movement in mice.Methods：Using the method of intragastric administration,to observe the acute toxicity of the crude and processed products of Entada phaseoloides in mice and determine their LD50.With the methods of charcoal propulsion of small intestine and methyl orange colorimetry of gastric emptying,to study the impact of the crude and processed products of Entada on gastrointestinal movement in mice.Results：The oral LD50 of crude Entada phaseoloides,No.1 and No.2 processed products of Entada phaseoloides in mice were 27.17,35.13,42.18 g/kg body weight.Crude and processed products of Entada phaseoloides can significantly promote the enteric propulsion of normal mice,and can significantly counteract the depressing status induced by atropine,but have no influence on the overactive status induced by neostigmine.The high,middle and low-dose of groups showed significant inhibition of the gastric emptying in normal mice.Conclusion：Processed Entada phaseoloides showed effects on the enteric propulsion of normal and depressing mice,can restrain the gastric emptying under normal mice,but its safety is better than crude Entada phaseoloides.

关 键 词：榼藤子 急性毒性 胃肠运动 炮制 

分 类 号：R283.1[医药卫生—中药学]