核素治疗骨关节炎的疗效观察  

Effect Observation of Radionuclide Therapy for Osteoarthritis

作　　者：魏敬军[1] 王育敏[1] 李益中[2] 刘景忠[3] 

机构地区：[1]兰州军区兰州总医院安宁分院核医学科,兰州730070 [2]兰州军区兰州总医院安宁分院骨科,兰州730070 [3]兰州军区兰州总医院安宁分院放射科,兰州730070

出　　处：《中国医药导刊》2010年第12期2074-2076,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨核素在治疗骨性关节炎中的作用,为防治老年骨性关节炎找出新的思路。方法:采用锝亚甲基二膦酸盐(99Tc-MDP,商品名:云克)静脉滴注与^(32)P-磷酸铬胶体关节腔注射相结合的方法治疗骨性关节炎,并与关节腔内注射玻璃酸钠(SH)治疗骨性关节炎进行早、中期比较。结果:早期(1个月)核素治疗组总有效率为97.44%、SH组总有效率为91.89%两组无显著差异,中期(6个月)核素治疗组总有效率为89.74%、SH组总有效率为70.27%,两组疗效差异显著。结论:锝亚甲基二膦酸盐静脉滴注与^(32)P-磷酸铬胶体关节腔注射相结合的方法治疗骨性关节炎疗效明显、安全可靠、且治疗效果时期长,是治疗早中期尚无需手术或不能耐受手术的骨性关节炎安全、有效的方法。Objective：To investigate the effect of radionuclide in the treatment of osteoarthritis and find new methods to prevent elderly osteoarthritis.Methods：The comparison of the therapies for the early and mid-term stage osteoarthritis were made between intravenous infusion of Tc-methylene diphosphonate（99Tc-MDP, trade name：Yun Ke）combined with intra-articular injection of 32P-Colloidal Chromium Phosphate and the intra-articular injection of sodium hyaluronate （SH）.Results：99Tc-MDP group and in SH group,the total effective rates were 97.44% and 91.89% respectively and there were no statistical differences between the two groups in the early stage （1 month）.But there were statistical differences between 9~Tc-MDP group and SH group in mid-term stage（6 month）and the total effective rates were 89.74% and 70.27% respectively. Conclusion：Intravenous infusion of 99Te-MDP combined with intra-articular injection of Colloidal Chromium Phosphate was effective in the treatment of osteoarthritis,especially for the patients who can not require or tolerate surgery in early and mid-term stage.

关 键 词：骨性关节炎 锝亚甲基二膦酸盐(99Tc-MDP) 32P-磷酸铬胶体 玻璃酸钠 

分 类 号：R684.3[医药卫生—骨科学]