眩晕宁治疗老年轻度认知障碍痰浊阻窍证的临床观察  

Clinical Effect of Xuanyunning Tablet in Treating Senile Patients with Mild Cognitive Impairment of Turbid-phlegm Blocking Orifice Syndrome

作　　者：朱黎明 

机构地区：[1]河南省洛阳市机车医院中西医结合科,洛阳471002

出　　处：《中国医药导刊》2010年第12期2107-2109,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨眩晕宁治疗老年轻度认知障碍(mild cognitive impairment,MCI)痰浊阻窍证的疗效。方法:全部100例MCI患者随机分为两组,治疗组(n=50)给予眩晕宁片,每次2片,每天3次,口服;对照组(n=50)给予吡拉西坦片,每次0.8g,每日3次,口服。两组均用药3个月。观察患者认知能力[简易精神状态检查(MMSE)]、中医症状积分、临床综合疗效(治疗效果、副作用)、海马体积及不良反应。结果:两组治疗后MMSE均升高,治疗组优于对照组,差异有显著意义(P<0.05)。治疗组治疗后除痰多吐涎外,其余各中医症状积分值均降低,且明显低于对照组,差异均有统计学意义(P<0.05或P<0.01)。治疗组疗效指数明显优于对照组(P<0.05),且治疗组治疗后总海马体积MRI定量明显优于对照组(P<0.05)。结论:眩晕宁可明显改善老年轻度认知障碍痰浊阻窍证患者的症状、认知能力并防止海马萎缩,有效预防轻度认知障碍向阿尔茨海默病的发展。Objective：To evaluate the clinical efficacy of Xuanyunning tablet in treating mild cognitive impairment （MCI）of turbid-phlegm blocking orifice syndrome.Methods：All 100 patients with MCI were randomly divided into treatment group （n=50） for Xuanyunning tablets,2 tablets each time,3 times a day, oral;the control group （n=50）were given Piracetam each 0.8,3 times a day orally. Both groups were medicated for 3 months.The cognition capacity [Mini-Mental State Examination （MMSE）],Chinese medicine syndrome integration,clinical comprehensive efficacy （treatment effect,side reaction）,hippocampal volume and adverse reactions were observed.Results： After treatment,MMSE in the treatment group were higher than those of the control group, the difference was significant （P〈0.05）.After treatment,expecting the expectoration,the remaining value of the TCM symptom scores of the treatment group were lower significantly,and lower than those of the control group,the differences were statistically significant （P〈0.05 or P〈0.01）.Effective index of the treatment group significantly better than that of the control group （P〈0.05）,and the total MRI quantitative hippocampal volume of the treatment group was significantly better than that of the control group （P〈0.05）.Conclusion：Xuanyunning tablet can improve symptoms,cognitive ability and prevent hippocampal atrophy in senile patients with mild cognitive impairment of turbid-phlegm blocking orifice syndrome significantly,prevent mild cognitive impairment developing to Alzheimers disease.

关 键 词：轻度认知障碍 痰浊阻窍证 眩晕宁 海马 认知能力 

分 类 号：R255.3[医药卫生—中医内科学]