GLOBAL STABILITY OF ENDEMIC EQUILIBRIUM POINT OF BASIC VIRUS INFECTION MODEL WITH APPLICATION TO HBV INFECTION  

作　　者：Yu ZHENG Lequan MIN Yu JI Yongmei SU Yang KUANG 

机构地区：[1]Information Engineering School, University of Science and Technology Beijing, Beijing 100083, China. [2]Mathematics and Physics School, University of Science and Technology Beijing, Beijing 100083, China. [3]Department of Mathematics and Statistics, Arizona State University, Temp AZ 85287-1804, USA.

出　　处：《Journal of Systems Science & Complexity》2010年第6期1221-1230,共10页系统科学与复杂性学报（英文版）

基　　金：This research is supported by the National Natural Science Foundations of China under Grant No. 60674059, the 11th 5-Year Plan Key Research Project of China under Grant No. 2004BA721A03, the China National Key Special Project for the Preventions and Cures of Important Infectious Diseases under Grant No. 2008ZX10005- 006.

摘　　要：In this paper, the authors first show that if Ro ≤1, the infection free steady state is globally attractive by using approaches different from those given by Min, et a1.（2008）. Then the authors prove that if Ro 〉 1, the endemic steady state is also globally attractive. Finally, based on a patient＇s clinical HBV DNA data of anti-HBV infection with drug lamivudine, the authors establish an ABVIM. The numerical simulations of the ABVIM axe good in agreement with the clinical data.

关 键 词：Basic infection reproduction number clinical data simulation equilibrium point global stability HBV infection. 

分 类 号：N[自然科学总论]