冠心病患者血清PA和hs-CRP水平变化的探讨  

Study on Changes of Serum PA and hs-CRP Levels in Different Stages of Coronary Heart Disease

作　　者：薛志宏[1] 惠玉芬[1] 王兴宁[1] 

机构地区：[1]延安大学附属医院,陕西延安716000

出　　处：《现代检验医学杂志》2010年第6期135-137,共3页Journal of Modern Laboratory Medicine

摘　　要：目的 探讨冠心病患者血清PA和hs-CRP水平的变化及实验检测价值.方法 选取临床确诊为冠心病患者107例,其中稳定型心绞痛（SAP）患者39例,不稳定型心绞痛（UAP）患者36例,急性心肌梗死（AMI）患者32例,采用免疫比浊法检测PA和hs-CRP的水平浓度.结果 SAP,UAP与AMI患者PA水平浓度逐渐降低,AMI患者血清PA水平浓度明显低于SAP,UAP患者（P＜0.01）;血清hs-CRPP水平浓度逐渐升高,AMI患者hs-CRP水平明显高于SAP与UAP患者（P＜0.01）;随病情严重程度增加hs-CRP浓度显著升高,PA浓度显著降低,差异均有统计学显著性意义（P＜0.01）.结论 血清PA和hs-CRP水平变化与冠心病发生、发展及预后密切相关.Objective To study the changes of serum PA and hs-CRP levels in different stages of coronary heart disease. Methods Of 107 CHD cases,there were 39 patients with stable angina,36 patients with unstable angina,32 patients with acute myocardial infarction,PA and hs-CRP levels were determined by immunoturbidimetry. Results From SAP patients to UAP patients arid to AMI patients,the PA level decreased gradually and the PA level of AMI were significantly lower than SAP and UAP patlents（P〈0.01）. The hs-CRP level increased gradually,the hs-CRP level of AMI were significantly higher than SAP and UAP patients（P〈0.01）. With progression of patient＇s condition to get worse,the PA level gradually decreased while the hs-CRP level gradually increased and the difference was significant（P〈0. 01）. Conclusion Serum PA and hs-CRP levels were closely related with occurrence development and prognosis of coronary heart disease.

关 键 词：冠心病 前清蛋白 超敏C-反应蛋白 炎症 

分 类 号：R541.4[医药卫生—心血管疾病] R446.112[医药卫生—内科学]