一氧化氮和内皮素-1在新生儿缺氧缺血性脑病中的作用  

Investigation of cerebrospinal fluid nitric oxide and endothelin 1 levels in neonatal anoxic ischemic encephalopath.

作　　者：刘晓红[1] 黄跃堂[1] 刘皖君[2] 

机构地区：[1]武汉市儿童医院新生儿科,430016 [2]同济医科大学附属同济医院儿科

出　　处：《实用儿科临床杂志》1999年第6期321-322,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的　研究新生儿缺氧缺血性脑病(HIE)患儿脑脊液一氧化氮(NO)和内皮素-1(ET-1)水平变化,探讨NO 和ET-1在HIE中的作用及相互关系。方法　检测24 例HIE患儿脑脊液NO和ET-1 水平,并与8 例对照组比较。结果　HIE组患儿脑脊液NO 和ET-1 水平明显高于对照组(P< 0.05),中、重度HIE组患儿脑脊液NO 和ET-1水平明显高于轻度HIE组(P< 0.05),头颅CT异常HIE患儿脑脊液ET-1 水平明显高于CT正常者(P< 0.01)。结论　NO和ET-1 参与新生儿HIE的病理生理过程,脑脊液NO和ET-1Objective To study the change of cerebrospinal fluid(CSF) nitric oxide(NO) and endothelin 1 (ET 1) levels in neonatal hypocic ischemic encephalopathy (HIE),and explore the role of NO and ET 1 in pathogenesis of neonatal HIE and the relationship of each other. Methods CSF NO and ET 1 levels were measured in 24 newborn infants with HIE,and 8 neonates served as controls. Results CSF NO and ET 1 levels were much higher in newborn infants with HIE compared with the control group( P <0.05);and the severe,and the moderate HIE higher than the mild HIE( P< 0.05);CSF ET 1 levels were significantly elevated in HIE of abnormal CT,in comparison with the normal CT group( P <0.01). Conclusion NO and ET 1 are significant to the pathgeresis of neonatal HIE.CSF NO and ET 1 levels are the important index for brain damage.

关 键 词：缺氧缺血性脑病 新生儿 一氧化氮 内皮素1 

分 类 号：R722.12[医药卫生—儿科]