血管内皮细胞生长因子在急性肺损伤中的作用  

Vascular endothelial growth factor in acute lung injury

作　　者：张曌[1] 张诗海[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院麻醉科,武汉430022

出　　处：《国际麻醉学与复苏杂志》2010年第6期532-534,共3页International Journal of Anesthesiology and Resuscitation

摘　　要：急性肺损伤（acute lurg injury,ALI）和急性呼吸窘迫综合征（acute respiratory distressyndrome,ARDS）的特征性病理改变为肺毛细血管通透性增高所致的肺水肿,血管内皮细胞生长因子能抗血管内皮细胞凋亡并增加血管通透性,可能在ALI和ARDS的病理过程中起到重要作用.现对血管内皮细胞生长因子在ALI中的作用进行综述,旨在为ALI和ARDS的治疗提供新的思路.Increased permeability and interstitial pulmonary edema are prominent features of acute lung injury （ALI）/acute respiratory distress syndrome（ARDS）.Vascular endothelial cell growth factor（VEGF） has been identified by its properties to increase permeability and act as a cellular growth factor, thus it is a potential key role in the pathogenesis of ALI/ARDS. Understanding the role of VEGF in this disease process is crucial for developing new therapeutic strategies for ALI/ARDS.

关 键 词：血管内皮细胞生长因子 急性肺损伤 急性呼吸窘迫综合征 

分 类 号：R563.8[医药卫生—呼吸系统]