颈动脉内-中膜厚度及踝肱指数与冠心病的相关性研究  

Relationship between carotid intima media thickness and ankle-brachial index in patients with coronary heart disease

作　　者：王新成[1] 李国庆[2] 

机构地区：[1]石河子大学医学院,新疆石河子832003 [2]新疆维吾尔自治区人民医院心内科,新疆乌鲁木齐830000

出　　处：《现代生物医学进展》2010年第23期4491-4493,共3页Progress in Modern Biomedicine

摘　　要：目的:通过研究颈动脉内-中膜厚度(carotid Intimal medial thickness cIMT)及踝肱指数(ankle-brachial index,ABI)与冠心病患者的相关性,探讨动脉硬化和动脉粥样硬化之间的相关性。方法:本研究入选264例在本院行冠脉造影的患者,按冠脉造影的结果分为对照组和冠心病组,冠心病组根据冠脉病变程度进一步分为单支、双支、多支病变组。所有入选者在冠脉造影前用日本ALOKAα7超声检测cIMT,用日本科林无创动脉硬化测定仪测量两侧ABI。结果:冠心病组cIMT明显高于对照组,踝臂指数明显低于对照组,差异有统计学意义(P<0.05);冠状动脉病变程度分析中:cIMT随着冠脉病变程度加重均有增高趋势,其中多支病变、双支病变组cIMT和颈动脉斑块积分均高于单支病变组、对照组,单支病变组cIMT和颈动脉斑块积分也明显高于对照组;ABI却随着冠脉病变程度加重均有降低趋势,多支病变组ABI均低于双支、单支病变组和对照组,双支、单支病变组ABI也明显低于对照组,差异有统计学意义(P<0.05)。结论:cIMT和ABI与冠心病密切相关,在一定程度上可以预测冠心病冠脉病变程度。Objective：By detecting ankle-brachial index and carotid intima media thickness in the patients with coronary heart disease,to investigate the relationship between coronary stiffness and coronary arthrosclerosis.Methods：Two hundred and sixty-four patients who were performed by coronary angiography（CAG） were divided into two groups according to the result of CAG：coronary heart disease group and control group.Coronary heart disease group was divided into single-vessel group,dual-vessel group and multi-ple-vessel group in term of the extent of coronary artery.cIMT was detected by ALOKAα7 Doppler examination,ABI was measure by a Colin system.Results：cIMT was significantly higher in coronary heart disease group compared with those in control group.In the analy-sis of the degree of coronary artery disease,cIMT increased gradually with the extent of coronary artery.cIMT and plaques score in those with multiple-vessel disease group and dual-vessel disease group were respectively higher than those with single-vessel disease group and control group.cIMT and plaques score in those with single-vessel disease group were respectively higher than those with control group;However,ABI decreased strongly wih the extent of coronary,ABI in those with multiple-vessel disease group were respectively lower than those with single-vessel disease group and dual-vessel disease group and control group,single-vessel disease group and dual-vessel disease group were significantly lower than those in control group（P0.05）.Conclusion：cIMT and ABI are strongly related with coro-nary heart disease,to some extents may predicting severe coronary artery lesions.

关 键 词：颈动脉内-中膜厚度 踝肱指数 动脉硬化 冠心病病变程度 

分 类 号：R541.4[医药卫生—心血管疾病]