乌苯美司对小鼠的免疫促进作用  

ENHANCEMENT OF UBENIMEX ON MOUSE IMMUNE SYSTEM

作　　者：陆瑶华[1] 凌骝[1] 张毅[1] 翟晓波[1] 沈炜明[1] 

机构地区：[1]上海市第六人民医院临床药学研究室,上海200233

出　　处：《中国医药工业杂志》1999年第11期502-505,共4页Chinese Journal of Pharmaceuticals

摘　　要：观察乌苯美司（１）对正常及免疫缺陷小鼠绵羊红细胞（ＳＲＢＣ）和噁唑酮诱发的迟发性超敏反应（ＤＴＨ）的影响。低剂量（０．１、１、１０ 或１００ μｇ／只）能促进对ＳＲＢＣ的ＤＴＨ 反应，恢复噁唑酮引起的ＤＣＨ 损伤，１的该作用有年龄依赖性；高剂量（１０００ μｇ／只）则无此作用。１ 亦能恢复环磷酰胺ｉｖ 给药或ｉｐ 接种Ｅｈｒｌｉｃｈ 腹水瘤细胞后引发的ＤＴＨ反应。结果表明，１ 能促进细胞介导的免疫反应，并恢复降低的细胞介导免疫反应功能。Effect of ubenimex (1) on the delayed type hypersensitivity (DTH) induced by sheep red blood cells (SRBC) and oxazolone was observed in normal and immunity impaired mice. Administration of a low dose of 1 (0.1～100 μg/mouse) enhanced DTH induced by SRBC and restored DTH impaired (oxazolone). The effect of 1 in the mouse was age dependent. In all cases, the highest dose of 1 (1 mg/mouse) did not enhance DTH response. 1 also restored DTH response impaired by injection of cyclophosphamide or inoculation with Ehrlich ascites tumour intraperitoneally. These results indicate that 1 enhances the cell mediated immune response and restores the reduced cell mediated immune reactions.

关 键 词：乌苯美司 细胞介导 免疫反应 

分 类 号：R979.5[医药卫生—药品]