胎儿生长迟缓与胰岛素及其相关代谢指标的相关性研究  

A study on the association between fetal growth retardation and the levels of insulin and related metabolic index

作　　者：张家勇[1] 潘燕群[1] 钟晓[1] 

机构地区：[1]广东省中山市南方医科大学附属小榄医院儿科,广东中山528415

出　　处：《湖南中医药大学学报》2010年第12期10-12,共3页Journal of Hunan University of Chinese Medicine

基　　金：中山市科技计划项目20082A08162

摘　　要：目的探讨胎儿生长迟缓(FGR)与新生儿胰岛素敏感性的关系。方法对50例小于胎龄儿(SGA)和40例适于胎龄儿(AGA)的空腹血糖(FPG)、空腹胰岛素(FINS)、C肽、HDL-C、LDL-C、TG、非酯化脂肪酸(NEFA)进行测定,计算葡萄糖/胰岛素比值(G/I)、胰岛素敏感性指数(ISI)等。结果 SGA组FINS、LDL-C、TG、NEFA高于AGA组,而FPG、HDL-C低于AGA组(P<0.01);SGA组G/I、ISI低于AGA组(P<0.01)。结论胎儿生长迟缓在生命早期存在胰岛素敏感性降低和不同程度的胰岛素抵抗(IR)。Objective To explore the relationship between fetal growth retardation（FGR）and the change of insulin sensitivity in neonates.Methods 50 small for gastational age in fants（SGA）and 40 appropriate-for-gestational-age infants（AGA）were selected,Fasting plasma glucose（FPG）,fasting insulin（FINS）,high density lipoprotein-cholesterol（HDLC）,low density lipoprotein-cholesterol（LDL-C）,Triglyceride（TG）and non-esterified fatty acids（NEFA）were assayed;glucose/insulin ratio（G/I）/insulin sensitvity index（ISI）were calculated.Results（1）The level of FINS、LDL-C、 TG and NEFA in SGA group was higher than that in AGA group,but the level of FPG and HDL-C was lower（P0.01;（2）G/I ratio,ISI in SGA group were lower than that in AGA group（P0.01）.Conclusion In early postnatal life FGR neonates display decreased insulin sensitivity and insulin resistance（IR）to some extent.

关 键 词：胎儿生长迟缓 胰岛素敏感性 胰岛素抵抗 

分 类 号：R725.8[医药卫生—儿科]