TLR9的特性及其介导的TLR9/CpG-DNA免疫信号通路  

The characteristics of TLR9 and the immunity signal path of TLR9/CpG-DNA

作　　者：桑丽敏[1] 唐立[1] 

机构地区：[1]大连医科大学微生态学教研室,辽宁大连116044

出　　处：《中国微生态学杂志》2010年第12期1143-1146,1149,共5页Chinese Journal of Microecology

基　　金：国家自然基金(30670045);国家"973"科学计划项目(2007CB513006);国家"863"科学计划项目(2007A10Z356)

摘　　要：TLRs在天然免疫应答中发挥着重要作用,构成了机体抗感染的第一道防线,是沟通天然免疫和获得性免疫的桥梁。其中TLR9已经被证实能够识别细菌DNA中免疫刺激序列CpG,从而激活哺乳动物细胞的天然免疫机制,这一发现具有重要的生物学意义与应用价值。它不仅进一步推进了外源DNA激活哺乳动物抗感染天然免疫的进一步研究,更为CpG-DNA应用于抗感染、肿瘤和免疫缺陷疾病等的治疗提供新的思路,为改进DNA疫苗效果提供非常有益的帮助。TLRs play an important role in natural immunization.They are the first line of resistance to infection,and the communication bridge of natural immunization and acquired immunization.TLR9 has been proved to be able to identify CPG-DNA in bacteria,and then activates mammalian cells natural immune system.The discovery has great biological significance and application value.It not only propels further study o the DNA which activates natural immunization,but also provides new ideas for the treatment of infection,tumor and immunodeficiency diseases by CpG-DNA,and helps in improving the effectiveness of DNA vaccine.

关 键 词：TOLL样受体 CPG-DNA 信号转导 髓性分化因子88 

分 类 号：R392.11[医药卫生—免疫学]