放疗前后荷瘤小鼠及肿瘤患者的体重变化观察  

The Observation about the Change of the Body Weight for Tumor Patients And the Bearing Tumor mice in Radiotherapy

作　　者：吴迪军[1] 鞠永健[1] 宁莉燕[1] 吴宏[1] 王高仁[1] 高璇[1] 汤娅红[1] 

机构地区：[1]南通市第一人民医院放疗科,江苏南通226001

出　　处：《中国辐射卫生》2010年第4期387-388,共2页Chinese Journal of Radiological Health

基　　金：国家自然科学基金资助项目(10705016);江苏省自然科学基金资助项目(BK2007553)

摘　　要：目的观察肿瘤患者及荷瘤小鼠放疗前后的体重变化。方法对63例肿瘤患者放疗前后的体重分别进行测量并与治疗疗程中位数时间间隔内的23例健康志愿者体重变化数据进行比较分析。另将45只成功接种人乳腺癌细胞SK-BR-3的裸鼠分为肿瘤部位接受照射及不照射的两组,分别在照射开始前和结束后进行体重测量并对体重变化数据进行分析。结果照射组小鼠体重变轻,而未照射组小鼠体重增加,两组小鼠体重变化各自均有统计学意义,两组小鼠的体重变化也存在显著的统计学差异。63例肿瘤患者及其中的鼻咽癌、食道癌及肺癌共四组患者平均体重都是减轻的但只有鼻咽癌、肺癌患者的体重减轻有显著的统计学意义。同一时间间隔内正常人的体重是保持的。四组患者中,除食道癌患者外,其余三组患者与正常人的体重变化数据比较均有显著差异。结论肿瘤患者放疗期间可能会体重减轻,应密切关注此变化对治疗的影响。Objective To observe the change of the body weight for tumor patients and the bearing tumor mice in radiotherapy.Methods For 63 tumor patients,the body weight（BW） were measured before and afetr radiotherapy respectively,and then the change of BW were compared and analyzed with that of 23 healthy volunteers at the median treatment period.Also 45 mice bearing human galactophore tomor cells SK-BR-3 were divided into irradiation and non-irradiation groups,and the change of BW for these two groups were measured and analyzed.Results The average BW decreases in the irradiation groups＇ mice but increase in the non-irradiation groups＇ mice,and the change of BW in these two groups has the statistical significance respectively,also the difference between these two goups has the statistical significance.For the four groups＇ tumor patients including 63 tumor patients as a whole,the nasopharynx cancer,esophagus cancer and lung cancer,the average BW decreases,but only in nasopharynx cancer and lung cancer groups the statistical significance are found.And at the same period,the BW of healthy volunteers are maintained.Compared change of BW in the four tumor groups with that in the healthy volunteers respectively,except the esophagus cancer group,the statistical significance are found in the other three groups.Conclusion For tumor patients,perhaps the BW will lose in the period of radiotherapy,so the effect of lose of BW must be cared about.

关 键 词：放射疗法 肿瘤 体重 

分 类 号：R815[医药卫生—放射医学]