ANP基因多态性对AMS发生及低氧习服效果的影响  

The Effects of Polymorphisms of ANP on the Incidence and the Hypoxia Acclimatization to Acute Mountain Sickness

作　　者：周文婷[1] 胡扬[1] 徐飞[2] 

机构地区：[1]北京体育大学,北京100084 [2]浙江工业大学体育科学研究所,浙江杭州310023

出　　处：《北京体育大学学报》2010年第12期45-47,共3页Journal of Beijing Sport University

基　　金：科技部奥运攻关课题(2006BAK12B01)

摘　　要：目的:研究ANP基因多态性对急性高山病(AMS)发生及低氧习服效果的影响。方法:Phase 1:模拟海拔4 800 m低氧环境中,61名北方汉族大学生急性暴露6 h,入舱30 min后以恒定负荷蹬车20min。Phase 2:恢复1周后,48名受试者进行3周渐进式低氧运动。恢复1周,重复Phase 1。PCR-RFLP法解析C-664G及T2238C位点基因型。结果:低氧运动后,62.5%的受试者低氧耐受力增强,AMS发生率由49.2%降至18.7%。C-664G和T2238C位点不同基因型和等位基因携带者的AMS发生率和AMS评分变化趋势不显著。结论:IAE辅以运动对AMS发生及低氧习服效果显著,ANP基因多态性与此无关。Objectives： To study the effects of polymorphisms of ANP at C-664G and T2238C loci on the incidence and the hypoxia acclimation to Acute Mountain Sickness（AMS）.Methods： Phase 1： 61 students,all male Chinese Han origin lowlanders,were involved in a 6h acute exposure to 4800m altitude-equivalent.Within 30 min of arriving at altitude,volunteers exercised at constant work rate for 20 min on a cycle ergometer（70r/min）.Phase 2： After 1wk of rest,48 volunteers completed an exercise performance testing in a 3wk period of IAE（2h/d,4d/wk）.After restoring 1wk,Phase 1 was repeated.Incidence and severity of AMS symptoms were determined using the LLS.PCR-RFLP was used to determine the genotypes and alleles frequencies of ANP at C-664G and T2238C loci.Results： After the altitude exercise,62.5% volunteers won better hypoxia tolerance while the AMS incidence rate is decreasing from 49.2% to 18.7%.But there are no significant differences in AMS score trends in different genotypes and allele carriers at C-664G and T2238C loci.Conclusions： Training in intermittent altitude exposures is remarkable effective for the hypoxia acclimation to AMS.No association exists between polymorphisms of ANP and the incidence of AMS as well as the hypoxia acclimation to AMS.

关 键 词：基因多态 急性高山病 发生率 低氧习服 

分 类 号：R594.3[医药卫生—内科学]