妊娠高血压疾病患者内脂素和VE-cadherin的含量变化  

The change of visfatin and VE-cadherin content of patients with hypertensive disorders in pregnancy

作　　者：苏文华[1] 周永勤[1] 班开斌[1] 黄友敏[2] 

机构地区：[1]山东省滕州市中心人民医院妇产科 [2]山东省滕州市中心人民医院输血科

出　　处：《医学检验与临床》2010年第6期18-20,25,共4页Medical Laboratory Science and Clinics

摘　　要：目的 研究妊娠期高血压疾病患者静脉血清及胎儿脐血中内脂素（visfatin）和血管内皮细胞钙黏蛋白（VE-cadherin）的含量变化及意义.方法 采用酶联免疫吸附法（ELISA）进行内脂素和VE-cadherin含量的测定,分别测定90例妊娠期高血压疾病患者（其中妊娠期高血压、轻度子痫前期、重度子痫前期各30例）及30例正常对照组产妇静脉血清及胎儿脐血中内脂素和VE-cadherin的含量.结果 内脂素和VE-cadherin在妊娠期高血压疾病组及对照组血清及胎儿脐血中均有表达.VE-cadherin在妊娠期高血压疾病各组血清中含量与对照组血清中的比较,差异有显著意义（t=7.31,9.82,10.04,P值均〈0.05）,且重度子痫前期组明显高于轻度子痫前期和妊娠期高血压组（t=7.23,8.95,P值均〈0.05）;轻度子痫前期组明显高于妊娠期高血压组（t=7.68,P〈0.05）.内脂素在妊娠期高血压疾病各组血清中含量与对照组血清中的比较,差异有显著意义（t=7.83,9.85,10.51,P值均〈0.05）,且重度子痫前期组明显高于轻度子痫前期和妊娠期高血压组（t=7.68,8.73,P值均〈0.05）;轻度子痫前期组明显高于妊娠期高血压组（t=7.69,P〈0.05）.妊娠期高血压疾病患者内脂素和VE-cadherin含量呈正相关（r=0.67,P〈0.01）.内脂素和VE-cadherin在妊娠期高血压疾病各组胎儿脐血中的含量,差异无显著意义（P〉0.05）.结论 内脂素和VE-cadherin的高表达说明,妊娠期高血压疾病患者内皮细胞损伤,且内脂素和VE-cadherin在损伤过程中起作用.Objective To investigate the expression and signficance of visfatin and VE- eadherin in intravenous serum and umbilical cord blood of patients with hypertensive disorders in pregnancy （pregnancy - induced hypertension syndrome, PIH）. Methods Contents of visfatin and VE - eadherin in inlravenons serum and umbilical cord blood from 90 patients with hypertensive disorders in pregnancy （which were divided into gestafional hypertension, mild and severe preeelampsia groups each including 30 patients） were detected by enzyme- linked immunnsorbent assay（ELISA） respectively. 30 normal pregnant women were taken as control group. Results Visfatin and VE- eadherin expressed in both patients and controls. Serum contents of VE - eadherin in patients and controls had significant difference by comparison （t = 7. 31,9.82,10.04, all P 〈 0.05） . Moreover, there were differences among the contents of three groups（t = 7.23,8.95,7.68, all P 〈 0.05）. Serum contents of visfatin in patients and controls had significant difference by comparison （t = 7.83,9.85,10.51, all P 〈 0.05）. Moreover, there were differences among the contents of three groups（t = 7.68,8.73, 7.69, all P 〈 0.05 ）. Contents of visfatin and VE- cadherin of pa- tients with hypertensive disorders in pregnancy showed a positive correlation （ r = 0.67, P 〈 0.01 ）. There were no significant differences in contents of visfatin and VE- cadherin in umbilical cord blood of patients with hypertensive disorders in pregnancy in three groups（P 〉 0.05）. Conclusion The high expression of visfatin and VE - eadherin in patients with hypertensive disorders in pregnancy indicates the injury of vaseular endothelium cells and visfatin and VE - cadherin play a role in the process of injury.

关 键 词：妊娠期高血压疾病 内脂素 血管内皮细胞钙黏蛋白 脐血 

分 类 号：R331[医药卫生—人体生理学]