美长安联合舒丽启能或/和赛乐特治疗腹泻型肠易激综合征的随机对照性研究  

A randomized,controlled study: enteric-coated capsule of bacillus subtilis and enterococcus joint trimebutine maleate tablets and/or paroxetine tablets in the treatment of diarrhea-predominant irritable bowel syndrome

作　　者：范开春[1] 王娟[1] 李贞[1] 郭明洲[1] 杨云生[1] 

机构地区：[1]解放军总医院消化内科,北京100853

出　　处：《胃肠病学和肝病学杂志》2011年第1期60-63,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的比较美长安(化学名称:枯草杆菌肠球菌二联活菌肠溶胶囊)联合舒丽启能(化学名称:马来酸曲美布汀片)或/和赛乐特(化学名称:盐酸帕罗西汀片)治疗腹泻型IBS的有效性和安全性。方法 131例腹泻型IBS病人连续随机地分为A组:枯草杆菌肠球菌二联活菌肠溶胶囊组;B组:枯草杆菌肠球菌二联活菌肠溶胶囊+马来酸曲美布汀片组;C组:枯草杆菌肠球菌二联活菌肠溶胶囊+盐酸帕罗西汀片组;D组:枯草杆菌肠球菌二联活菌肠溶胶囊+马来酸曲美布汀片+盐酸帕罗西汀片组。治疗3周后观察病人的排便次数、大便性状、腹痛腹胀情况及不良反应。结果对于治疗后大便次数,A、B、C、D四组总有效率分别为35.48%、63.89%、36.67%、67.65%。A组与B组、A组与D组、C组与D组比较差异有统计学意义(P<0.05)。对于治疗后腹痛腹胀,四组总有效率分别为35.48%、61.11%、56.67%、91.18%。A组与B组、A组与C组、A组与D组、B组与D组、C组与D组比较差异有统计学意义(P<0.05)。对于治疗后大便性状,四组总有效率分别为41.94%、75.00%、40.00%、79.41%。A组与B组、A组与D组、B组与C组、C组与D组比较差异有统计学意义(P<0.05)。结论单用枯草杆菌肠球菌二联活菌肠溶胶囊对腹泻型IBS是有效的,适合轻度腹泻型IBS。联合马来酸曲美布汀片对腹泻型IBS更有效,适合中度腹泻型IBS病人。再联合盐酸帕罗西汀片对于腹泻型IBS最有效,特别适合重型腹泻型IBS。Objective To compare the efficacy and safety of enteric-coated capsule of bacillus subtilis and enterococcus joint trimebutine maleate tablets and/or paroxetine in the treatment of diarrhea-predominant irritable bowel syndrome（D-IBS）. Methods A total of 131 consecutive outpatients with D-IBS were randomly divided into group A： treatment with enteric-coated capsule of bacillus subtilis and enterococcus;group B： treatment with enteric-coated capsule of bacillus subtilis and enterococcus joint trimebutine maleate;group C： treatment with enteric-coated capsule of bacillus subtilis joint paroxetine;group D： treatment with enteric-coated capsule of bacillus subtilis and enterococcus joint trimebutine maleate tablets and paroxetine tablets.Three weeks after treatment,the patients＇ stool frequency,abdominal pain and bloating,stool consistency and adverse reactions were observed and recorded. Results The total effective rates of stool frequency were 35.48%,63.89%,36.67%,67.65% respectively in the group A,the group B,the group C and the group D after treatment,and the difference between group A and group B,group A and group D,group C and group D were statistically significant （P0.05）.The total effective rates of abdominal pain and bloating were 35.48%,61.11%,56.67%,91.18% respectively in the group A,the group B,the group C and the group D after treatment,and the difference between group A and group B,group A and group C,group A and group D,group B and group D,group C and group D were statistically significant（P0.05）.The total effective rates of stool consistency were 41.94%,75.00%,40.00%,79.41% respectively in the group A,the group B,the group C and the group D after treatment,and the difference between group A and group B,group A and group D,group B and group C,group C and group D were statistically significant（P0.05）. Conclusion The enteric-coated capsule of bacillus subtilis was effective,more suitable for mild D-IBS.The enteric-coated capsule of bacillus subtilis joint trimebutine maleate tabl

关 键 词：肠易激综合征 枯草杆菌肠球菌二联活菌肠溶胶囊 马来酸曲美布汀片 盐酸帕罗西汀片 

分 类 号：R975[医药卫生—药品] R574.4[医药卫生—药学]