复合碱性功能单体分子烙印手性固定相  

Highly Efficient Molecule Imprinting Chiral Stationary Phase Utilizing Combined Basic Functional Monomers

作　　者：王进防[1] 周良模[1] 孟子晖[2] 王清海[1] 朱道乾[1] 

机构地区：[1]中国科学院大连化学物理研究所,大连116012 [2]中国人民解放军军事医学科学院六所,北京100850

出　　处：《化学学报》1999年第10期1147-1151,共5页Acta Chimica Sinica

基　　金：国家自然科学基金(29575212)资助项目

摘　　要：采用丙烯酰胺+2-乙烯基吡啶的复合碱性功能单体体系制备了氨基酸衍生物分子烙印高效液相色谱手性固定相.在优化了功能单体与烙印分子的比例条件下对于烙印分子及其结构相似的对映体具有良好的手性分离能力.考察了烙印分子的化学基因对手性分离的影响,发现氢键作用力和较强的离子作用力在手性分离过程中均有贡献.Molecular imprinting polymers (MIP) against amino acid derivatives utilizing amide plus 2 -vinylpyridine as combined basic functional monomers were prepared and evaluated as chiral stationary phase for high - performance liquid chromatography. The MIPs prepared at optimized ratio of the imprinting molecule to combined functional monomers show excellent chiral separation ability to the imprinting enantiomer and its structurally related enantiomers. The effect of chemical group of the analyse on the chiral separation was investigated. Hydrogen bonding and strong ionic interaction between the functional monomer and the analyse were found.

关 键 词：分子烙印聚合物 手性固定相 氨基酸衍生物 HPLC 

分 类 号：O657.720.3[理学—分析化学]