取代芳甲酰哌嗪新衍生物的合成及其药理活性  

SYNTHESIS AND POSITIVE INOTROPIC ACTIVITY OF SUBSTITUTED AROYL PIPERAZINE DERIVATIVES

作　　者：徐鸣夏[1] 周国川 杨艳[2] 谢益农[3] 刘智飞 曾晓荣 李瑞雪[1] 

机构地区：[1]华西医科大学药学院,成都610041 [2]沪州医学院,沪州646000 [3]四川大学,成都610064

出　　处：《化学研究与应用》1999年第5期523-524,共2页Chemical Research and Application

摘　　要：We designed and synthesized 5 new compounds. Their chemical structures were confirmed by means of MS, HNMR andelemental analysis. FPA was tested for positive inotropic activity. The results showed that FPA could increase the contrastive amplitudeof isolated atrium of guinea pigs and had no influence upon rhythm of the hearts.We designed and synthesized 5 new compounds. Their chemical structures were confirmed by means of MS, HNMR andelemental analysis. FPA was tested for positive inotropic activity. The results showed that FPA could increase the contrastive amplitudeof isolated atrium of guinea pigs and had no influence upon rhythm of the hearts.

关 键 词：取代芳甲酰基 哌嗪衍生物 正性肌力药 维司力农 

分 类 号：TQ463.5[化学工程—制药化工]