口服益生菌对新生儿高胆红素血症疗效及其免疫功能的影响  

Efficacy of oral probiotics and its effect on immunity in treating hyperbilirubinemia of neonates

作　　者：袁传顺[1] 陈吉庆[2] 陆超[2] 徐莉[1] 陈新跃[1] 杜娟[1] 张子前 周亚红[1] 

机构地区：[1]常州市第七人民医院,213011 [2]南京医科大学第一附属医院儿科

出　　处：《江苏医药》2011年第2期171-173,共3页Jiangsu Medical Journal

基　　金：常州市卫生局科技项目(WZ200810)

摘　　要：目的探讨口服益生菌佐治新生儿高胆红素血症的临床疗效及其对患儿免疫功能的影响。方法 68例高胆红素血症新生儿随机分为益生菌组(36例)和对照组(32例)。益生菌组在对照组光疗基础上连续加予益生菌口服14d。观察治疗前后新生儿血清总胆红素(TBil)水平变化、胃肠道不良反应及相关免疫学指标。结果治疗后益生菌组TBil水平明显低于对照组[(131.75±28.41)μmol/Lvs.(160.56±26.97)μmol/L](P<0.01)。外周血中CD4+细胞比例、CD4+/CD8+数值以及IgM水平[(0.55±0.16)g/Lvs.(0.29±0.14)g/L]较对照组均明显增加(P<0.01)。益生菌组胃肠道副作用发生率明显低于对照组(19.44%vs.46.88%)(P<0.05)。结论加服益生菌治疗新生儿高胆红素血症可以明显增加退黄疗效,促进机体免疫功能,降低治疗期间副作用。Objective To investigate the efficacy of oral probiotics and its effect on immunity in treating hyperbilirubinemia（HBM） of neonates.Methods Sixty-eight neonates with HBM were randomly divided into two groups.Group B（32 cases） was treated with phototherapy 12 hours per day for three days and group A（36 cases） was given additional oral probiotics for 14 days.Total serum bilirubin（TBil） and criteria of immunity were detected before and after treatment.Side effects were recorded as well.Results After treatment,TBil level was lower in group A than that in group B [（131.75±28.41） μmol/L vs.（160.56±26.97） μmol/L] （P0.01）.The percentage of CD4＋ T lymphocytes,the ratio of CD4＋ to CD8＋ and immunoglobulin M in peripheral blood were higher in group A than those in group B [（0.55±0.16） g/L vs（0.29±0.14） g/L] （P0.01）.Incidence of adverse intestinal symptoms was lower in group A than that in group B（19.44% vs 46.88%）（P0.05）.Conclusion Additional oral probiotics may improve the effect of phototherapy on HBM,promote immune function and reduce the side effects in HBM neonates on phototherapy.

关 键 词：高胆红素血症 免疫功能 益生菌 新生儿 

分 类 号：R722[医药卫生—儿科]