联合检测血清炎症因子对急性冠脉综合征的预测价值  

The value of serum inflammatory factors detection in predicting acute coronary syndrome

作　　者：李如意[1] 李秀芳[1] 刘永欣[1] 齐晓勇[1] 

机构地区：[1]河北省人民医院心脏中心,石家庄市050051

出　　处：《江苏医药》2011年第2期190-192,共3页Jiangsu Medical Journal

基　　金：河北省卫生厅医学科学研究重点课题(08016)

摘　　要：目的观察冠心病(CHD)患者血清炎症因子与急性冠脉综合征(ACS)的关系。方法入选20例ACS患者(ACS组)、20例稳定型心绞痛患者(SAP组)及20例对照者(C组),采用ELISA法测定血清基质金属蛋白酶(MMP)-9、MMP抑制物1(TIMP-1)水平,免疫散射比浊法测定血清高敏C反应蛋白(hs-CRP)。结果 ACS组患者血清hs-CRP、MMP-9、TIMP-1水平显著高于SAP组及C组(P<0.05);血清MMP-9与TIMP-1及hs-CRP之间均呈正相关(P<0.05)。结论在CHD患者,联合检测hs-CRP、MMP-9、TIMP-1有助于提高临床对ACS的预测和诊断。Objective To study the relationship between serum inflammatory factors and acute coronary syndrome（ACS） in patients with coronary heart disease（CHD）.Methods Immune nephelometry and ELISA assay were used to measure serum levels of high sensitive C-reactive protein（hs-CRP）,matrix metalloproteinase（MMP）-9,TIMP-1 in 20 ACS patients（group ACS）,20 patients with stable angina pectoris（group SAP） and 20 persons without CHD（group C）.Results The serum hs-CRP,MMP-9 and MMP inhibitor-1（TIMP-1） in group ACS were significantly higher than those in groups of SAP and C（P0.05）.The serum level of MMP-9 was positively correlated with TIMP-1 and hs-CRP（P0.05）.Conclusion Combined detection of serum level of hs-CRP with TIMP-1 and MMP-9 is helpful in predicting and diagnosing ACS in patients with CHD.

关 键 词：急性冠脉综合征 高敏C反应蛋白 基质金属蛋白酶9 基质金属蛋白酶抑制物1 

分 类 号：R541[医药卫生—心血管疾病]