抗肝片吸虫病药物化合物的合成及解偶联活性研究  

SYNTHESIS OF THE DRUG COMPOUNDS AGAINST PARASITE FASCIOLA HEPATICA AND STUDY ON THE UNCOUPLING ACTIVITY

作　　者：王晓晶[1,1] 赵军[1] 李哲[1] 新民[1] 

机构地区：[1]内蒙古大学化学系

出　　处：《化学研究与应用》1999年第4期422-424,共3页Chemical Research and Application

摘　　要：肝片吸虫是传播极为广泛的家畜体内寄生虫。文献报道N(2,4,5三氯)苯基2羟基3,5,6三氯苯磺酰胺(简称为HBSA)及其卤化衍生物是比较好的治疗肝片吸虫病药物,部分化合物已获美国专利[1]。经我们近几年对苯磺酰苯胺类化合物药物作用机理的研究初步证实:该类化合物是线粒体氧化...The substituted 2 hydroxylbenzenesulfonanilides compounds have been synthesized.The decoupling action of these compounds for oxidative phosphorylation in rat liver mitochondria were studied.Decoupling activities were measured by measuring stimulation of state 4 respiration and measuring the increase of Pi in reaction medium.

关 键 词：抗肝片吸虫病药 合成 杀虫剂 苯磺酰胺 解偶联 

分 类 号：TQ453.299[化学工程—农药化工]