Fe^(2+)-2,2′-联吡啶分光光度法测定针剂中头孢他啶含量  

Spectrophotometric Determination of Ceftazidime Using Iron(Ⅱ)-2,2′-Bipyrinine System

作　　者：沙鸥[1] 孙梅[1] 顾叶华[1] 曾珍[1] 

机构地区：[1]淮海工学院化学工程学院,江苏连云港222005

出　　处：《淮海工学院学报（自然科学版）》2010年第4期37-39,共3页Journal of Huaihai Institute of Technology:Natural Sciences Edition

基　　金：江苏省高校自然科学研究计划资助项目(09KJD430002);淮海工学院自然科学基金资助项目(Z2007045)

摘　　要：基于头孢他啶将Fe3+还原为Fe2+,生成的Fe2+与2,2′-联吡啶形成桔红色配合物,建立了Fe2+-2,2′-联吡啶分光光度法测定头孢他啶的新方法,头孢他啶标准溶液质量浓度在0.4～10 mg/L范围内与吸光度呈良好线性关系,线性回归方程为ΔA=0.079 73ρ+0.045 08,线性相关系数r=0.996 0。该法用于针剂中头孢他啶的含量分析,结果令人满意。A new method for the determination of ceftazidime by spectrophotometry was developed based on Fe^3＋ as the oxidizer of ceftazidime and 2,2′-dipyridine as the coloring reagent of Fe^2＋ , which was produced from Fe^3＋. Under the optimum conditions, the relationship between the ahsorbance and the concentration of ceftazidime was linear in the range of 0.4-10 mg/L, the regression equation was △A= 0. 079 73ρ（mg/L） ＋0. 045 08, and the relative coefficient was 0. 996 0. The proposed method has been applied to the determination of ceftazidime content in samples with satisfactory results.

关 键 词：分光光度法 头孢他啶 2 2′联吡啶 

分 类 号：O657.32[理学—分析化学]