代谢综合征与无症状脑梗死的相关性研究  

Correlation between metabolic syndrome and silent cerebral infarction:a cross-sectional study

作　　者：乙成成[1] 刘雯雯[1] 张颖秋[1] 王湘芸[1] 郭志军[1] 殷仁富[1] 

机构地区：[1]第二军医大学附属长征医院贵宾诊疗科,上海200003

出　　处：《第三军医大学学报》2011年第4期408-410,共3页Journal of Third Military Medical University

摘　　要：目的探讨代谢综合征（metabolic syndrome,MS）及其各组分与无症状脑梗死（silent cerebral infarction,SCI）的相关性。方法连续收集我科2006年5月至2010年6月健康体检患者959例[男性693例,女性266例,年龄（49.8±9.1）岁],根据修订后的中国人代谢综合征诊断标准,将所有患者分为代谢综合征组（443例）和非代谢综合征组（516例）。比较两组患者无症状脑梗死的患病率并采用单因素和多因素Logistic回归法分析代谢综合征及其各组分与无症状脑梗死的相关性。结果单因素统计分析发现代谢综合征组罹患无症状脑梗死的比例明显高于非代谢综合征组（41.1%vs27.5%,P〈0.000 1）。多因素Logistic回归分析显示代谢综合征与无症状脑梗死发病明显相关（OR=1.73,95%CI：1.24~2.41,P=0.001 2）,在代谢综合征各组分内高血压（OR=1.40,95%CI：1.05~1.88,P=0.023 0）、糖尿病（OR=1.75,95%CI：1.23~2.48,P=0.001 9）也是无症状脑梗死的独立危险因素,而其他组分无统计学意义。结论代谢综合征与无症状脑梗死关系密切,代谢综合征是无症状脑梗死的独立危险因素。Objective To determine whether metabolic syndrome（MS） is correlated with silent cerebral infarction（SCI）.Methods A cross-sectional study of 959 health-screening subjects（693 men and 266 women,at a mean age of 49.8±9.1） who underwent a physical examination in our department from May 2006 to March 2010 was carried out.These individuals were then divided into MS group and non-MS group according to the modified criterion established by the Chinese Medical Association of Diabetes.Prevalence of SCI,was evaluated by the results of MIR scanning.Two groups were compared and the correlation between MS and SCI were analyzed by univariate and multivariate logistic regression analysis.Results The prevalence of SCI was much higher in MS group than in non-MS group（41.1% vs 27.5%,P0.01）.Univariate analyses revealed that significant correlation was found between MS and SCI（Chi square=19.6,P0.01）.Multivariate logistic analyses revealed that MS was significantly associated with SCI（OR=1.73,95%CI： 1.24-2.41,P=0.001 2）.The components model of MS showed a strong significance between hypertension（OR=1.40,95%CI： 1.05-1.88,P=0.023 0） and diabetes mellitus（OR=1.75,95%CI： 1.23-2.48,P=0.001 9） and the risk of SCI.Conclusion There is a close correlation between MS and SCI.MS is an independent risk factor of SCI.

关 键 词：代谢综合征 无症状脑梗死 危险因素 

分 类 号：R181.32[医药卫生—流行病学] R589[医药卫生—公共卫生与预防医学]