来氟米特治疗常复发性肾病综合征的疗效研究  

Therapeutic Effect of Leflunomide in Treating Refractory Primary Nephrotic Syndrome

作　　者：崔彤霞[1] 朱伟平[1] 钱白音[1] 

机构地区：[1]中山大学附属第五医院肾内科,广东省珠海市519000

出　　处：《中国全科医学》2010年第36期4129-4131,共3页Chinese General Practice

摘　　要：目的探讨来氟米特联合激素治疗常复发性肾病综合征是否能减少复发并延长缓解时间。方法对42例激素治疗敏感但反复复发的原发性肾病综合征患者,使用来氟米特联合激素治疗,观察完全缓解后的持续缓解时间。结果治疗3个月后42例患者均完全缓解,随访过程中,21例(50.0%)4年未复发,15例(35.7%)3年未复发,其余6例(14.3%)2年未复发。采用激素+来氟米特治疗的患者平均持续缓解时间明显长于单用激素治疗者及激素+其他药物治疗者,差异有统计学意义(P<0.01)。结论来氟米特联合激素治疗能延长常复发性肾病综合征的持续缓解时间,减少复发次数。Objective To investigate the effect of leflunomide combined with hormone on the relapse and remission period of refractory primary nephrotic syndrome.Methods Forty-two hormone-sensitive patients with refractory primary nephrotic syndrome were treated with leflunomide combined with hormone.After complete remission,continue complete remission（CCR） time was observed.Results All 42 cases had complete remission after 3 month′s treatment.Follow-up survey showed that 21 cases（50.0%） had 4 years continue complete remission,15 cases（35.7%） had 3 years continue complete remission,and the other 6 cases（14.3%） had 2 years continue complete remission.Patients who adopt the treatment of leflunomide combined with hormone had a significantly longer continue complete remission than those who used only hormone or hormone combined with other medicines（P〈0.01）.Conclusion Leflunomide combined with hormone can prolong continue complete remission and reduce relapse times in treating refractory primary nephritic syndrome.

关 键 词：来氟米特 常复发性肾病综合征 缓解时间 

分 类 号：R692[医药卫生—泌尿科学]