缺血后适应对急性心肌梗死患者介入治疗疗效的影响  

Effect of Ischemic Postconditioning on the Outcome of Patients with Acute Myocardial Infarction Treated with Percutaneous Coronary Intervention

作　　者：于翔[1] 卢成志[1] 蔡林[1] 赵向东[1] 徐建强[1] 张峰[1] 张菁[1] 

机构地区：[1]天津市第一中心医院心内科,300192

出　　处：《中国全科医学》2010年第36期4135-4136,共2页Chinese General Practice

摘　　要：目的观察缺血后适应(PC)对急性心肌梗死(AM I)患者经皮冠状动脉介入治疗术(PCI)治疗疗效的影响。方法选取接受急诊PCI治疗的AM I患者98例,分为PC组(n=51)和非缺血后适应(NPC)组(n=47)。测定两组患者的校正心肌梗死溶栓试验帧数(CTFC),血清肌酸激酶峰值、肌酸激酶同工酶峰值,术后1周、1个月及3个月的左室射血分数。结果 PC组与NPC组比较,CTFC、肌酸激酶峰值、肌酸激酶同工酶峰值间差异均有统计学意义(P<0.01);PCI术后1周、1个月两组患者的左室射血分数间差异均无统计学意义(P>0.05),而PCI术后3个月,PC组的左室射血分数高于NPC组,差异有统计学意义(P<0.01)。结论缺血后适应可以显著改善AM I患者PCI治疗后冠状动脉血流速度及心功能。Objective To evaluate the effect of ischemic postconditioning on the outcome of patients with acute myocardial infarction（AMI） treated with percutaneous coronary intervention（PCI）.Methods 98 acute myocardial infarction patients treated with percutaneous coronary intervention were randomly divided into ischemic postconditioning（PC） group（n=51） and non-ischemic postconditioning（NPC） group（n=47）.Corrected TIMI frame count（CTFC）,creatine kinase（CK）,MB isoenzyme of creatine kinase（CK-MB） and left ventricular ejection fraction（LVEF） one week,one month and three months after operation were assessed.Results The difference of the levels of CTFC,creatine kinase（CK）,MB isoenzyme of creatine kinase（CK-MB） were significant between the two groups（P〈0.01）.The difference of left ventricular ejection fraction（LVEF） one week and one month after operation between the two groups were not significant（P〉0.05）.However,after three month,left ventricular ejection fraction（LVEF） in PC group was significantly higher than that of NPC group（P〈0.01）.Conclusion Ischemic postconditioning can improve the coronary blood flow velocity and heart function of AMI patients treated with percutaneous coronary intervention（PCI）.

关 键 词：缺血后适应 急性心肌梗死 血管成形术 经腔 经皮冠状动脉 治疗结果 

分 类 号：R542.22[医药卫生—心血管疾病]