磺化β-环糊精手性添加剂毛细管电泳对映体拆分的研究  

A Study of Sulfated β-Cyclodextrin Chiral Additive for Enantiomeric Separation by Capillary Electrophoresis

作　　者：阮宗琴[1] 陆豪杰[1] 尤进茂[1] 欧庆瑜[1] 

机构地区：[1]中国科学院兰州化学物理研究所,兰州730000

出　　处：《分析化学》1999年第8期907-911,共5页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金;兰州化学物理研究所所长择优基金资助项目

摘　　要：将平均取代度为6.5的负电性磺化β-环糊精手性添加剂应用于毛细管电泳对映体拆分的研究中.在不同电极性条件下,考察了背景电解质pH值及磺化β-环糊精浓度对手性拆分的影响,并应用磺化β-环糊精拆分酸性、碱性和中性的手性化合物.An anionic chiral resolving agent, sulfated β-cyclodextrin with average substitute degree 6.5,was employed as chiral additive for enantiomeric separation by capillary electrophoresis. In differentelectrophoretic polarity mode, the effects of pH of background electrolyte, the concentration of sulfated β-cyclodextrin were investigated. Sulfated β-cyclodextrin proved to be strong complexing agents for charged(basic, acidic) , and non-charged analytes for chiral separation.

关 键 词：毛细管电泳 磺化 环糊精 手性添加剂 对映体拆分 

分 类 号：O657.803[理学—分析化学]