微针治疗浅表血管性病变的实验研究  

Study on microneedle in the treatment of vascular dermopathy

作　　者：孙玉[1] 韦强[1] 陈宝峰[1] 马珂[1] 

机构地区：[1]广西医科大学第一附属医院整形外科,南宁市530021

出　　处：《微创医学》2010年第6期560-562,共3页Journal of Minimally Invasive Medicine

摘　　要：目的探讨微针联合不同药物对浅表部位血管性病变的疗效。方法选用30只莱亨鸡,随机分成3组,每组10只。以鸡冠作为血管病变的动物模型,采用微针联合平阳霉素与曲安奈德处理鸡冠,依次为A、B两个实验组,正常鸡冠作为空白对照组C,分别在处理后的1周、2周、3周、4周动态观察鸡冠组织的大体及组织学变化,统计毛细血管的数目。结果实验组鸡冠均有不同程度颜色变浅变淡,镜下观察真皮下毛细血管减少,A组表现明显大于B组。结论微针滚磨的机械作用和药物作用均能有效地作用于鸡冠的毛细血管,联用平阳霉素效果要好于曲安奈德。Objective To explore the efficacy of microneedle combined with different drugs on superficial parts vascular lesions.Methods 30 Laiheng chickens were randomly divided into 3 groups,each group of 10 only.Cockscomb as an animal model of vascular lesions,microneedle combined with pingyangmycin（group A） and triamcinolone acetonide（group B） were adopted,normal comb as control group C.Dynamic observation of dilated organization general and pathological changes,capillary number of change were done 1,2,3,4 weeks after processing respectively.Results The comb in experimental groups showed shallow and pale,in varying degrees,microscopic observation showed that dermal capillary decreased,group A was significantly greater than group B.Conclusion Roller grinding of microneedle and drug interactions can be effective on the dilated blood capillary,and the effect of pingyangmycin is better than that of triamcinolone acetonide.

关 键 词：微针 血管性病变 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]