母体氟暴露对仔代胸腺酶组化与超微结构的影响  

EFFECTS OF EXPOSURE TO FLUORIDE ON THE THYMIC ULTRASTRUCTURE AND ENZYENEHISTOCHEMISTRY FOR LILIAL GENERATION

作　　者：陈培忠[1] 孙红琰[2] 秦玉平[1] 乔赐彬 孟宪才[1] 高红旭[1] 

机构地区：[1]山东省地方病防治研究所 [2]中国军事医学科学院 [3]山东省劳动卫生研究所

出　　处：《中国地方病防治》1999年第6期324-326,共3页Chinese Journal of Control of Endemic Diseases

基　　金：山东省卫生厅计划立项并基金资助课题

摘　　要：本文观察了小鼠母体氟暴露对仔代胸腺酶组织化学与超微结构的影响,结果显示:(1)酶组化观察中发现高剂量组仔鼠胸腺AKP、ACP、Ca^(2+)-ATP酶活性显著降低;(2)高剂量染氟组仔鼠胸腺电镜下可见上皮细胞、胸腺细胞核染色质固缩成块状且分布不均;线粒体嵴断裂或消失;上皮细胞与胸腺细胞之间连接松弛,间隙增大等。表明氟化物可损伤胸腺细胞,胸腺上皮细胞,直接或间接影响胸腺细胞的发育,进而导致后代的免疫功能降低。In order to study the relation between fluoride and immune function of boby, the effects of maternal exposure to fluoride on the thymic ultrastructure and enzyenehistochemistry for fetus mice were observed in this paper. Results showed that at the high dose NaF group, the mucleus chromatin of thymic epithelial cells and their crest loss or despeared; the mitochondria were swelling, the density of plasma decreased and their crest loss or dispeared; the bond of epithelial cells with thymo-cytes became loose and the gap between them became wide.The result of enzyenehistochemistry showed that the activity of AKP, ACPand Ca - ATPase of thymus in fetus mice decreased markedly in epithelial reticular cell or thymocyte compared with the control. This indicated that fluoride may injure thymic epithelial cell and thymocyte, and affected direct or indirectly growth of thymocyte.

关 键 词：氟 胸腺 酶组织化学 超微结构 仔鼠 氟中毒 

分 类 号：R599.9[医药卫生—内科学]