局部用减充血剂后出现鼻阻力反弹现象的研究  

The rebound of nasal resistance after decongestant used in nose

作　　者：沈锦雄[1] 黄选兆[1] 项济生[1] 舒宏[1] 

机构地区：[1]同济医科大学附属协和医院耳鼻咽喉科,武汉430022

出　　处：《临床耳鼻咽喉科杂志》1999年第12期560-561,共2页Journal of Clinical Otorhinolaryngology

摘　　要：目的：探讨局部用减充血剂对鼻粘膜血管运动调控的影响，为研究和防治药物性鼻炎提供理论依据。方法：调查92例急、慢性鼻炎患者分别使用4种不同减充血剂后鼻塞变化的情况；并通过前鼻测压法观察部分患者用药后鼻阻力的反弹现象。结果：4组被调查者中分别有63．5％，31．2％，32．2％，8．6％的患者出现鼻塞反弹性加重；3组被检测者中分别有50％，20％和75％出现鼻阻力反弹性升高。结论：局部用减充血剂可以引起鼻阻力的反弹性升高，其发生率与患者的病情及使用的药物有关；调控鼻粘膜血管运动的舒血管机制被激活，可能是其产生的机理。Objective:To investigate the effect of decongestant on nasal resistance so as to provide theoriesfor studing rhinitis medicamentosa. Method:The changes of nasal blockage in 92 cases of acute rhinitis and chro-nic rhinitis after using decongestants were recorded, and the nasal resistance in 39 cases were measured by activeanterior rhinomanometry. Result: According to the diseases and decongestents used, the percentage of nasal resis-tance rebound were 63. 5%,31. 2 %, 32. 2%, 8. 6% in 4 groups of investopted patients and 50%,20%,75 % in3 groups of measured patients respectively. Couclusion:Decongestants can cause the rebound of nasal resistance,which relates to the diseases and the decongestants used. The mechasm may be that the factors dilating thevasa in nasal mucosa are activated.

关 键 词：鼻血管收缩药 鼻阻力 鼻炎 鼻堵塞 

分 类 号：R765.210.5[医药卫生—耳鼻咽喉科] R987[医药卫生—临床医学]