二氧化氮致大鼠急性肺损伤及其机理探讨  

Studies on the acute lung injury caused by nitrogen dioxide in rats and its mechanism

作　　者：宋蔚忠[1] 夏亚东[1] 郭绪益 闻思真[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《军事医学科学院院刊》1999年第4期263-265,268,共4页Bulletin of the Academy of Military Medical Sciences

摘　　要：目的：探讨ＮＯ２ 致急性肺损伤机理。方法：大鼠静式吸入染毒，观测肺组织病理变化及肺泡灌洗液中蛋白和ＬＤＨ 含量，同时测定肺组织抗氧化物及丙二醛（ＭＤＡ）的含量。结果：大鼠吸入ＮＯ２ 后，肺组织明显损伤，同时ＧＳＨ－ＰＸ、ＳＯＤ、维生素Ｅ、总巯基含量显著降低，ＭＤＡ 含量也明显下降，肺损伤越重，各指标下降越明显，随着肺损伤的修复，各指标也恢复正常。结论：ＮＯ２Objective: To study the mechanism of acute lung injury induced by NO 2. Methods: A chamber without air diffusion was used for NO 2 exposure. Pathology of lung, contents of protein and lactate dehydrogenase in bronchioalveolar lavage fluid and contents of antioxidant and malondialdehyde(MDA) in lungs were examined after rats were exposed to NO 2. Results: After exposure to NO 2, lungs were injured , contents of glutathione peroxidase, superoxide dismutase, vitamin E and sulfhydryl in lungs decreased significantly, and so did MDA. All changes showed dose effect relatim and returned to control level with lungs repaired. Conclusion: These results suggest that decreases in antioxidants may have contribution to acute lung injury caused by NO 2.

关 键 词：二氧化氮 急性 肺损伤 脂质过氧化 

分 类 号：R563.02[医药卫生—呼吸系统]