环磷酰胺冲击治疗系统性红斑狼疮心脏损害疗效观察  

Cyclophosphamide Pulse Therapy for Cardiac Lesion in Systemic Lupus Erythromatosus

作　　者：彭新海[1] 韦明欣 

机构地区：[1]江苏连云港市第二人民医院肾内科 [2]广西区人民医院肾内科

出　　处：《广西医学》1999年第6期1092-1096,共5页Guangxi Medical Journal

摘　　要：目的 :观察环磷酰胺 (CTX)冲击治疗系统性红斑狼疮 (SLE)心脏损害的疗效。方法 :将 60例 SLE心脏损害患者分为二组 :治疗组 (n=30 )用 CTX冲击 ,每 2周 1次 ,每次 8- 12 mg/ kg,连用 2天 ,累积总量≤150 mg/ kg,同时口服强的松每日 1mg/ kg,8周后减量 ,每周减 10 %至隔日 1mg/ kg,再逐渐减至隔日 0 .4mg/kg维持。对照组 (n=30 )仅用以上强的松治疗。结果 :与对照组相比 ,治疗组病情缓解率高 (P〈0 .0 1) ,心功能指标改善显著 (P〈0 .0 1) ,其复发率和死亡率低 (P〈0 .0 1)。结论 :对 SLE心脏损害特别是心功能不全的患者 ,CTX冲击疗效显著优于单用激素。Objective:To investigate the efficacy of cyclophosphamide(CTX) pulse therapy for cardiac lesion in systemic lupus erythromatosus (SLE) Methods:60 patients with cardiac lesion secondary to SLE were ramdonly assigned into 2 groups 30 patients in treatment group reseived 8-12mg/kg of CTX every two weeks until the accumulated dose reaches ≤150mg/kg 1mg/kg of prednisone was given simultaneously for 8 weeks and then tapered 30 patients in control group received prednisone only Results:Patients in treatment group had higher remission rate (P<0 01),better cardiac function (P<0 01) Lower relapse rate,and reduced mortality rate (P<0 01) than in the control group Conclusions: CTX pulse therapy is superior to prednisone alone in controlling cardiac lesion,especially heart failure secondary to SLE

关 键 词：环磷酰胺 系统性红斑狼疮 心脏损害 药物疗法 

分 类 号：R593.241[医药卫生—内科学] R541[医药卫生—临床医学]