微核糖核酸对血管生成相关因子的调节作用  

The Regulation of MicroRNAs in Angiogenesis Factors

作　　者：于潇华[1] 郭小芳[1] 田智[1] 粟敏[1] 刘立鹏[1] 

机构地区：[1]长沙医学院基础医学系,中国湖南长沙410219

出　　处：《生命科学研究》2010年第6期560-564,共5页Life Science Research

基　　金：湖南省自然科学基金资助项目(7JJ3058)

摘　　要：微核糖核酸(microRNAs,miRNAs)是广泛存在于真核生物中的一类短小的、非编码的单链RNA,由18～25个核苷酸组成,在调节细胞增殖、分化、凋亡和肿瘤发生等多种生物学过程中起重要作用.血管生成过程中受到多种血管生成因子的调控作用,近期研究表明,microRNAs参与血管生成相关因子的调节,进而影响血管生成,然而具体的功能以及作用机制仍需探讨.进一步研究microRNAs对血管生成相关因子的调控作用,为心血管疾病和肿瘤的治疗提供新的理论基础.MicroRNAs（miRNAs） is an abundant class of small non-coding RNAs,which is single-stranded RNA of 18~25nt in eukaryotes.Researches have showed that microRNAs has play an important role in regulating many biological processes,such as proliferation,differentiation,apoptosis and carcinogenesis.Recent studies have shown that microRNAs is involved in the regulation of angiogenesis factor,which affected angiogenesis by adjusting these factors,however the specific function and mechanism of microRNAs in angiogenesis still needs investigation.Further studying the role of microRNAs in angiogenesis factors will provide new theoretical foundation for the treatment of cardiovascular disease and cancer.

关 键 词：MICRORNAS 血管生成 缺氧诱导因子 血管内皮生长因子 

分 类 号：R543.7[医药卫生—心血管疾病] R34[医药卫生—内科学]