区域动脉灌注联合腹腔灌洗治疗重症急性胰腺炎临床分析  

Regional arterial infusion combined with peritoneal lavage for severe acute pancreatitis

作　　者：王双全 杨俊[1] 王刚[1] 

机构地区：[1]陕西中医学院附属西电医院肝胆外科,西安710077

出　　处：《临床外科杂志》2010年第6期375-377,共3页Journal of Clinical Surgery

摘　　要：目的比较不同给药途径治疗重症急性胰腺炎（SAP）的效果。方法48例SAP患者，随机分为三组：治疗组17例，采用血管介入区域动脉药物灌注加腹腔灌洗；对照Ⅰ组16例，在外周血管给药基础上加腹腔灌洗；对照Ⅱ组15例，仅常规外周血管给药治疗。观察三组患者腹痛、腹胀症状缓解时问，氧分压、血常规、淀粉酶降至正常时间、平均住院时间及并发症、死亡率等相关指标。结果腹部症状缓解时间、血淀粉酶恢复时间、住院时间及并发症发生率方面，治疗组各项指标均低于对照组，差异有统计学意义（P〈0．05）。对照Ⅰ组与对照Ⅱ组相比，总体疗效优越，但差异无统计学意义（P〉0．05）。结论区域动脉灌注联合腹腔灌洗治疗SAP疗效优越。血管介入方法安全可行，其为治疗SAP开辟了良好治疗途径，具有一定的临床应用价值。Objective To examine the therapeutic efficacy of the different route of administration to treat severe acute pancreatitis （SAP）. Methods Forty - eight patients with SAP were divided randomly into three groups： Treatment group （n = 17 ） , in which 17 patients were treated by regional arterial infusion combined with peritoneal lavage; control group Ⅰ （n = 16 ） , in which 16 patients were given peritoneal lavage and periphery vein injection ;control group Ⅱ （n = 15 ） , in which 15 patients were subjec- ted to a mere periphery vein injection. Abdominal signs and pain relief time ,time to recover intestinal function, partial pressure of oxygen, blood routine, time for amylase level returning to the normal, the average hospital stay, complications, mortality and other related indicators were observed and compared between groups. Results In terms of the indicators including abdominal symptoms and signs, blood amylase recovery time, hospitalization time, complication rate, the treatment group showed better efficacy than the control group （ P 〈 0.05 ）. The indicators in the control group Ⅰ were not significantly different from those in the control group Ⅱ （ P 〉 0.05 ）. Conclusion Regional arterial infusion combined with peritoneal layage is effective in the treatment of SAP. Vascular interventional technique is feasible and safe when used for the treatment of SAP.

关 键 词：重症急性胰腺炎 动脉药物灌注 腹腔灌洗 

分 类 号：R657.51[医药卫生—外科学]