四氧嘧啶致小鼠、大鼠糖尿病模型研究  

Study on the Model of Diabetic Mice and Rat Induced by Alloxan

作　　者：肖小华[1] 徐丽瑛[1] 朱令元[1] 丁琦[1] 

机构地区：[1]江西省药物研究所,江西南昌330029

出　　处：《科技广场》2010年第10期112-114,共3页Science Mosaic

摘　　要：目的:研究四氧嘧啶尾静脉注射小鼠和大鼠诱导糖尿病模型,观察不同剂量四氧嘧啶诱导糖尿病模型的稳定性。方法l分别对小鼠尾静脉注射四氧嘧啶60、70、80mg/kg和对大鼠尾静脉注射四氧嘧啶30、40、50mg/kg,测定不同时点小鼠和大鼠的血糖值及体重。结果60、70和80mg/kg四氧嘧啶剂量均可导致小鼠糖尿病模型,但70和80mg/kg剂量组小鼠死亡率较大,而60mg/kg组小鼠糖尿病模型稳定;30mg/kg四氧嘧啶剂量不能造成大鼠糖尿病模型,40和50mg/kg四氧嘧啶剂量均可导致大鼠糖尿病模型,但四氧嘧啶50mg/kg剂量组大鼠死亡率较大,只有40mg/kg组糖尿病大鼠模型稳定。结论:造成小鼠和大鼠糖尿病模型最佳剂量分别为60mg/kg和40mg/kg。Objective：to study on diabetic mice and diabetic rat models which were induced by i.v.different dosage alloxan,and observe the stability of diabetic changes in mice and rats of different dosage alloxan.Method：with alloxan at the doses of 60,70,80mg/kg and 30,40,50mg/kg by i.v.administration to normal mice and rat,to measure their serum Glu and body weight at different time points.Result：the diabetes mice modle were induced succeessful by 60,70 and 80mg/kg dosage alloxan.Mice death rate of 70 and 80mg/kg dosage alloxan were bigger,and diabetic mice model of 60mg/kg dosage alloxan were steady.The diabetes rats modle were induced by 40 and 50mg/kg but 30mg/kg dosage alloxan,while rats death rate of 50mg/kg dosage alloxan were bigger and diabetic rats model of 40mg/kg dosage alloxan were steady.Conclusion：the result indicated the most fitful dosage were 60mg/kg to mice and 40mg/kg to rat.

关 键 词：四氧嘧啶 糖尿病 血糖 

分 类 号：Q95-33[生物学—动物学]