一种透皮无创血糖检测系统的设计与实验验证  

Development and experiment of a glucose monitor using noninvasive transdermal extraction

作　　者：肖宏辉[1,2] 常凌乾[1,2] 杨庆德[1,2] 贺银增[1,2] 蔡新霞[1,2] 

机构地区：[1]中国科学院电子学研究所传感技术国家重点实验室北方基地,北京100190 [2]中国科学院研究生院,北京100049

出　　处：《仪器仪表学报》2010年第12期2796-2802,共7页Chinese Journal of Scientific Instrument

基　　金：国家重点基础研究发展计划(2011CB933202);国家高技术研究发展计划(2007AA042105;2007AA04Z326);中科院知识创新项目(KGCX2-YW-916)资助

摘　　要：介绍了一种基于反离子电渗方法的非侵入式血糖监测系统。该系统通过集成恒电流源和双恒电势仪电路,配合高灵敏度介体酶传感器,实现了反离子电渗抽取和抽取至体表葡萄糖的检测。并且通过良好的降噪和提升采样精度的设计,有效提高了测量的准确性。根据所检测的葡萄糖浓度与组织液葡萄糖浓度以及血糖浓度间相对稳定的对应关系,本系统可以自动计算出血糖浓度。经过动物实验验证:该无创血糖监测系统经过一次有创校准后能够实现血糖监测。对比常规的有创测量方法,在动物血糖自然变化状态下,该系统的监测结果能够很好地反映出血糖的平均浓度值;在人为干预动物血糖浓度的情况下,该系统的监测结果能够较好地反映出血糖的变化趋势。A non-invasive glucose monitor based on reverse iontophoresis is described.The reverse iontophoresis method is realized with a constant current source,and the glucose obtained using reverse iontophoresis method is detected with a high-sensitivity enzyme biosensor and a double constant voltage source circuit.The accuracy of the monitor is improved by good noise depression design and high sample precision design.The monitor can figure out blood glucose through the relationship among the glucose detected by the biosensor,the glucose in tissues and blood glucose.Animal experiments were carried out to verify the monitor.The results show that the monitor can detect the variation of the experimental animal＇s blood glucose after an invasive instrument calibration.When the animal＇s blood glucose varies in normal status,the result of the monitor shows good correlation with the invasive instrument result.When the animal is injected with a mount of high concentration glucose,the monitor can detect the variation trend of blood glucose.

关 键 词：血糖 无创测量 反离子电渗 中国实验用小型猪 

分 类 号：TH77[机械工程—仪器科学与技术]