医院内感染葡萄球菌属耐药情况分析  

Analysis of drug-resistant of staphylococcus in nosocomial infections

作　　者：张文明[1] 郑玉龙[2] 吴飞霞[2] 万长标[2] 叶茂林[2] 

机构地区：[1]江苏省淮安经济开发区新南城社区卫生服务中心,淮安223005 [2]淮安市第二人民医院

出　　处：《临床医学》2010年第12期115-116,共2页Clinical Medicine

摘　　要：目的了解葡萄球菌属细菌的耐药情况,为临床合理使用抗生素提供参考。方法对本院2004年1月至2007年6月住院患者各类标本分离到的葡萄球菌属做药敏试验和耐甲氧西林测定。结果共分离到葡萄球菌属656株,金黄色葡萄球菌241株,耐甲氧西林葡萄球菌检出率为49.8%;凝固酶阴性葡萄球菌415株,耐药凝固酶阴性葡萄球菌检出率为51.1%;主要分离自血液、痰液、脓及伤口分泌物及尿液标本;以儿科、重症监护室和肿瘤患者为主;>60岁和<13岁的患者居多。结论葡萄球菌属感染逐年增长,耐甲氧西林菌株检出率高,耐药性强,且呈多重耐药性,做好感染监测,合理使用抗感染药物,提高治愈率。Objective To investigate the drug-resistance of staphylococcus,and provide the reference for clinical reasonable use of antibiotics.Methods The clinical isolated staphylococcus strains from January 2004 to June 2007 were collected and cultured.The antimicrobial susceptibility testing and methicillin-resistant testing were performed respectively.Results Total 656 staphylococcus strains were isolated form various clinical samples including blood,sputum,wound secretions and urine,in which 241 staphylococcus aureus and 415 coagulase-regative staphylococcus aureus were included.49.8% of staphyloccoccus aureus and 51.1% of coagulase-regative staphylococcus aureus were found to be Methicillin-resistant.Most staphylococcus aureus were isolated from patients of pediatrics,intensive care units（ICU） and oncology.Patients who were over than 60 years old and less than 13 years old were more.Conclusion Rate of infections due to staphylococcus aureus increased year by year,and the prevalence of methicillin-resistant staphylococcus aureus（MRSA） was also increased.Many MRSA were high drug-resistance and multidrug-resistance,so it is important to choose the appropriate antibiotics according to the result of drug sensitivity test and to improve the cure rate.

关 键 词：葡萄球菌属 耐甲氧西林 分布 耐药性 

分 类 号：R446.5[医药卫生—诊断学]