中国冠心病二级预防研究——血脂康明显降低癌症风险  

China Coronary Secondary Prevention Study—Xuezhikang Reducing the Risk of Cancer Occurrence and Mortality in Patients With Previous History of Myocardial Infarction

作　　者：寇文镕[1] 陆宗良[1] 陈祚[2] 武阳丰[3] 

机构地区：[1]中国医学科学院北京协和医学院心血管病研究所阜外心血管病医院冠心病诊治中心,北京市100037 [2]中国医学科学院北京协和医学院心血管病研究所阜外心血管病医院防治网络部,北京市100037 [3]北京大学医学部

出　　处：《中国循环杂志》2010年第6期445-448,共4页Chinese Circulation Journal

基　　金：国家"九五"科技攻关项目(96-906-02-10)

摘　　要：目的:探讨血脂康调整血脂的同时能否降低冠心病心肌梗死患者的癌症风险。方法:入选对象源自中国冠心病二级预防研究(CCSPS)暨血脂康调整血脂对冠心病二级预防多中心、随机、双盲、安慰剂对照的临床试验研究,符合入选标准的4 870例心肌梗死后的患者按1∶1随机分为血脂康治疗组(2 429例)与安慰剂组(2 441例),平均随访4年。本文仅就达到随诊终点的80例癌症患者为本文的分析对象,就两组发生的癌症事件与癌症死亡进行对比分析。结果:血脂康治疗组与安慰剂组比较,发生癌症事件与癌症死亡均降低[30例(3.1/1000人年)vs 50例(5.3/1000人年),P=0.019;13例(1.3/1000人年)vs 29例(3.1/1000人年),P=0.011],差异均有统计学意义。长期用血脂康治疗可降低癌症事件与死亡的相对风险分别为42.4%与57.4%。结论:本研究发现长期用血脂康治疗心肌梗死后患者发生癌症事件人数与癌症死亡人数明显降低。Objective：To identify the effect of a lipid-lowering medication,Xuezhikang（XZK）,reducing the risk of cancer occurrence and cancer mortality in patients with previous history of myocardial infarction（MI）.Methods：We summarized 4870 patients from China coronary secondary prevention study（CCSPS） from 1996 to 2003.The patients were randomly assigned into two groups,XZK group,n=2429,and Control group,n=2441,the patients took placebo.The mean follow-up time was 4 years,and 80 patieuts suffered from cancer during that period of time.The primary end points of cancer occurrence and mortality were compared in both groups.Results：Compared with Control group,the cancer occurrence and cancer mortality was lower in XZK group,50 patients（5.3/1000/year） vs.30 patients（3.1/1000/year）,P=0.019;and 29 patients（3.1/1000/year） vs.13 patients（1.3/1000/year）,P=0.011 respectively,those differences had the statistic meaning.Long term XZK medication decreased the relative risk of cancer occurrence and cancer mortality by 42.4% and 57.4% respectively.Conclusion：Our work indicated that the long-term medication of XZK could significantly reduce the risk of cancer occurrence and cancer mortality in patients with previous history of MI.

关 键 词：血脂康 心肌梗死 二级预防 癌症 

分 类 号：R541[医药卫生—心血管疾病]